403502-20-5Relevant articles and documents
Synthesis and anti-HIV-1 activity of new delavirdine analogues carrying arylpyrrole moieties
Pinna,Loriga,Murineddu,Grella,Mura,Vargiu,Murgioni,La Colla
, p. 1406 - 1411 (2007/10/03)
In our search for novel anti-human immunodeficiency virus (HIV)-1 agents, 14 delavirdine analogues were synthesized and evaluated as potential anti-HIV-1 agents in cell-based assays. Compound 1Aa exhibited potent and selective anti-HIV-1 activity in acutely infected MT4 cells, with effective concentration (EC50) values in the submicromolar range.