4036-83-3

Basic information

• Product Name: 2-MORPHOLINO-5-NITROBENZOIC ACID
• Synonyms: RARECHEM AL BE 1084;AKOS BB-8607;5-NITRO-2-(MORPHOLIN-4-YL)BENZOIC ACID;2-MORPHOLINO-5-NITROBENZOIC ACID;2-MORPHOLIN-4-YL-5-NITRO-BENZOIC ACID;ART-CHEM-BB B025600
• CAS NO: 4036-83-3
• Molecular Formula: C₁₁H₁₂N₂O₅
• Molecular Weight: 252.22
• Mol File: 4036-83-3.mol
• Article Data: 14

Chemical Properties

• Melting Point: 167-168
• Boiling Point: 481.4 °C at 760 mmHg
• Flash Point: 244.9 °C
• Appearance: /
• Density: 1.424 g/cm³
• Vapor Pressure: 4.47E-10mmHg at 25°C
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 2-MORPHOLINO-5-NITROBENZOIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 2-MORPHOLINO-5-NITROBENZOIC ACID(4036-83-3)
• EPA Substance Registry System: 2-MORPHOLINO-5-NITROBENZOIC ACID(4036-83-3)

Safety Data

• Hazard Codes: Xi
• HazardClass: IRRITANT
• Hazardous Substances Data: 4036-83-3(Hazardous Substances Data)

Usage

General Description

2-MORPHOLINO-5-NITROBENZOIC ACID is a chemical compound with the molecular formula C11H11N2O6. It is a nitrobenzoic acid derivative containing a morpholine ring, and it is commonly used as a biochemical research tool and as a reagent in organic synthesis. 2-MORPHOLINO-5-NITROBENZOIC ACID has been studied for its potential anti-inflammatory and anti-cancer properties. It has also been used in the development of pharmaceuticals and in the study of the structure and function of proteins. Additionally, 2-MORPHOLINO-5-NITROBENZOIC ACID has been investigated for its role in the synthesis of new materials and for its potential applications in various industries.

InChI:InChI=1/C11H12N2O5/c14-11(15)9-7-8(13(16)17)1-2-10(9)12-3-5-18-6-4-12/h1-2,7H,3-6H2,(H,14,15)/p-1

Upstream product

• 110-91-8 morpholine 
• 2516-96-3 2-chloro-5-nitrobenzoic acid 
• 943-14-6 2-bromo-5-nitrobenzoic acid 
• 7304-32-7 2-fluoro-5-nitrobenzoic acid 
• 445-29-4 o-fluoro-benzoic acid 
• 17417-09-3 2-fluoro-5-nitrobenzonitrile 

Downstream Products

• 83909-31-3 5-Amino-2-morpholin-4-yl-benzoic acid; hydrochloride 
• 847971-78-2 2-(4-morpholinyl)-5-nitrobenzoyl chloride 
• 310415-30-6 1-{4-[4-(2-morpholin-4-yl-5-nitro-benzoyl)-piperazin-1-yl]-3-fluoro-phenyl}-ethanone 
• 1079817-13-2 C₂₂H₂₆N₄O₄ 
• 1079817-10-9 C₂₂H₂₆N₄O₅ 
• 1079817-15-4 C₂₂H₂₃F₃N₄O₄ 

Relevant articles and documents

Discovery of novel 2-phenylamino-4-prolylpyrimidine derivatives as TRK/ALK dual inhibitors with promising antitumor effects

In order to explore novel TRK and ALK dual inhibitors, a series of 2-phenylamino-4-prolylpyrimidine derivatives were designed, synthesized and evaluated for their in vitro cytotoxicity and enzymatic activities. Delightfully, most compounds were detected m

The discovery of novel small molecule allosteric activators of aldehyde dehydrogenase 2

Aldehyde dehydrogenase 2 (ALDH2) plays important role in ethanol metabolism, and also serves as an important shield from the damage occurring under oxidative stress. A special inactive variant was found carried by 35–45% of East Asians. The variant carriers have recently been found at the higher risk for the diseases related to the damage occurring under oxidative stress, such as cardiovascular and cerebrovascular diseases. As a result, ALDH2 activators may potentially serve as a new class of therapeutics. Herein, N-benzylanilines were found as novel allosteric activators of ALDH2 by computational virtual screening using ligand-based and structure-based screening parallel screening strategy. Then a structural optimization was performed and has led to the discovery of the compound C6. It has good activity in vitro and in vivo, which could reduce infarct size by ～70% in ischemic stroke rat models. This study provided good lead compounds for the further development of ALDH2 activators.

ALDH2 agonist, preparation method and application thereof

The invention belongs to the technical field of medicines, and particularly relates to an ALDH2 agonist, a preparation method and application thereof. The ALDH2 agonist has a novel structure and excellent ALDH2 agonist activity.