40372-61-0

Basic information

• Product Name: 2-Amino-5-bromo-4-chlorophenol
• Synonyms: 2-Amino-5-bromo-4-chlorophenol
• CAS NO: 40372-61-0
• Molecular Formula: C6H5BrClNO
• Molecular Weight: 222.469
• Mol File: 40372-61-0.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 310.0±42.0 °C(Predicted)
• Density: 1.880±0.06 g/cm3(Predicted)
• CAS DataBase Reference: 2-Amino-5-bromo-4-chlorophenol(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Amino-5-bromo-4-chlorophenol(40372-61-0)
• EPA Substance Registry System: 2-Amino-5-bromo-4-chlorophenol(40372-61-0)

Safety Data

• Hazardous Substances Data: 40372-61-0(Hazardous Substances Data)

Usage

Chemical compound

2-Amino-5-bromo-4-chlorophenol

Physical properties

Pale yellow solid

Molecular weight

216.47 g/mol

Uses

Manufacturing of hair dyes and colorants, synthesis of pharmaceuticals and organic compounds

Safety precautions

Harmful if ingested or inhaled, can cause skin and eye irritation upon contact

Upstream product

• 102170-53-6 4-bromo-5-chloro-2-methoxyaniline 
• 855400-82-7 5-bromo-4-chloro-2-nitrophenol 
• 89-61-2 2,5-dichloronitrobenzene 
• 95-03-4 5-chloro-2-methoxyaniline 
• 89-21-4 4-chloro-2-nitroanisole 

Downstream Products

• 1345117-89-6 N-[5-(5-chloro-2-methylbenzoxazol-6-yl)(2-pyridyl)](2-chlorophenyl)carboxamide 
• 1346665-54-0 N-[4-(5-chloro-2-methylbenzoxazol-6-yl)phenyl](2-fluorophenyl)carboxamide 
• 1346665-53-9 4-(5-chloro-2-methylbenzoxazol-6-yl)phenylamine 
• 1346667-63-7 N-[4-(5-chloro-2-methylbenzoxazol-6-yl)phenyl](3-fluoro(4-pyridyl))carboxamide 
• 1361379-06-7 [5-(5-chloro-2-methylbenzoxazol-6-yl)(2-thienyl)]-N-(2-chlorophenyl)carboxamide 
• 1361379-07-8 [5-(5-chloro-2-methylbenzoxazol-6-yl)(2-thienyl)]-N-(2-fluorophenyl)carboxamide 
• 1361379-08-9 [5-(5-chloro-2-methylbenzoxazol-6-yl)(2-thienyl)]-N-(2,6-difluorophenyl)carboxamide 
• 1366109-75-2 C₁₉H₁₂ClFN₂O₂Se 
• 5579-85-1 5,7-dibromo-6-hydroxy-2H-1,3-benzoxathiol-2-one 
• 1345117-76-1 N-[5-(5-chlorobenzoxazol-6-yl)(2-pyridyl)](2-chlorophenyl)carboxamide 

Relevant articles and documents

RIFAMYCIN ANALOGS AND ANTIBODY-DRUG CONJUGATES THEREOF

The disclosure relates to rifamycin analog compounds, intermediates and precursors thereof, and pharmaceutical compositions capable of inhibiting bacterial growth (e.g., S. aureus growth) and treating bacterial infections (e.g., S. aureus infections). The disclosure further relates to antibody-drug conjugates of rifamycin analog compounds and antibodies, for example, antibodies specific for infectious disease-related targets such as membrane glycoprotein receptor (MSR1), wall teichoic acids (WTA) or Protein A, and methods of use thereof to inhibit bacterial growth and treat bacterial infections.

3-(5-CHLORO-2-OXOBENZO[D]OXAZOL-3(2H)-YL)PROPANOIC ACID DERIVATIVES AS KMO INHIBITORS

A compound of formula (I) or a salt thereof are provided wherein R1, X and R3 are defined in the specification, useful in the treatment of disorders mediated by KMO such as acute pancreatitis, chronic kidney disease, other conditions associated with systemic inflammatory response syndrome (SIRS), Huntington's disease, Alzheimer's disease, spinocerebellar ataxias, Parkinson's disease, AIDS-dementia complex, amylotrophic lateral sclerosis (ALS), depression, schizophrenia, sepsis, cardiovascular shock, severe trauma, acute lung injury, acute respiratory distress syndrome, acute cholecystitis, severe burns, pneumonia, extensive surgical procedures, ischemic bowel, severe acute hepatic disease, severe acute hepatic encephalopathy or acute renal failure.

COMPOUNDS THAT MODULATE INTRACELLULAR CALCIUM

Described herein are compounds and pharmaceutical compositions containing such compounds, which modulate the activity of store-operated calcium (SOC) channels. Also described herein are methods of using such SOC channel modulators, alone and in combinatio