4038-97-5 Usage
Description
7-Methoxy-4-(piperazin-1-yl)quinoline is a quinoline derivative with a molecular formula of C16H19N3O. It features a piperazine moiety attached to the fourth position, which contributes to its potential pharmacological properties. 7-METHOXY-4-(PIPERAZIN-1-YL)QUINOLINE has been of interest in medicinal chemistry and neuroscience due to its possible affinity for neurotransmitter receptors in the brain.
Uses
Used in Pharmaceutical Industry:
7-Methoxy-4-(piperazin-1-yl)quinoline is used as a serotonin receptor antagonist for its potential role in the development of drugs targeting conditions such as anxiety, depression, and schizophrenia. Its molecular structure and pharmacological effects make it a promising candidate for further research and development in the field of medicinal chemistry.
Used in Drug Development:
7-Methoxy-4-(piperazin-1-yl)quinoline is utilized in the development of novel therapeutic agents that may help in managing neurological and psychiatric disorders. Its interaction with neurotransmitter receptors suggests that it could be a key component in creating effective treatments for various mental health conditions.
Check Digit Verification of cas no
The CAS Registry Mumber 4038-97-5 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 4,0,3 and 8 respectively; the second part has 2 digits, 9 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 4038-97:
(6*4)+(5*0)+(4*3)+(3*8)+(2*9)+(1*7)=85
85 % 10 = 5
So 4038-97-5 is a valid CAS Registry Number.
InChI:InChI=1/C14H17N3O/c1-18-11-2-3-12-13(10-11)16-5-4-14(12)17-8-6-15-7-9-17/h2-5,10,15H,6-9H2,1H3
4038-97-5Relevant articles and documents
Engineering another class of anti-tubercular lead: Hit to lead optimization of an intriguing class of gyrase ATPase inhibitors
Jeankumar, Variam Ullas,Reshma, Rudraraju Srilakshmi,Vats, Rahul,Janupally, Renuka,Saxena, Shalini,Yogeeswari, Perumal,Sriram, Dharmarajan
, p. 216 - 231 (2016/07/07)
A structure based medium throughput virtual screening campaign of BITS-Pilani in house chemical library to identify novel binders of Mycobacterium tuberculosis gyrase ATPase domain led to the discovery of a quinoline scaffold. Further medicinal chemistry explorations on the right hand core of the early hit, engendered a potent lead demonstrating superior efficacy both in the enzyme and whole cell screening assay. The binding affinity shown at the enzyme level was further corroborated by biophysical characterization techniques. Early pharmacokinetic evaluation of the optimized analogue was encouraging and provides interesting potential for further optimization.
