403839-05-4

Basic information

• Product Name: 3-Quinolinecarboxylic acid, 4-[[(3-chloro-4-methoxyphenyl)methyl]amino]-6-cyano-
• CAS NO: 403839-05-4
• Molecular Formula: C19H14ClN3O3
• Molecular Weight: 367.791
• Mol File: 403839-05-4.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 3-Quinolinecarboxylic acid, 4-[[(3-chloro-4-methoxyphenyl)methyl]amino]-6-cyano-(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Quinolinecarboxylic acid, 4-[[(3-chloro-4-methoxyphenyl)methyl]amino]-6-cyano-(403839-05-4)
• EPA Substance Registry System: 3-Quinolinecarboxylic acid, 4-[[(3-chloro-4-methoxyphenyl)methyl]amino]-6-cyano-(403839-05-4)

Safety Data

• Hazardous Substances Data: 403839-05-4(Hazardous Substances Data)

Upstream product

• 26832-90-6 diethyl 2-(4-cyanophenylamino)methylenemalonate 
• 403838-46-0 ethyl 4-[(3-chloro-4-methoxybenzyl)amino]-6-cyanoquinoline-3-carboxylate 
• 403841-76-9 4-chloro-6-cyanoquinoline-3-carboxylic acid ethyl ester 

Downstream Products

• 403839-11-2 4-[[(3-Chloro-4-methoxyphenyl)methyl]amino ]-6-quinolinecarbonitrile 
• 403839-14-5 4-[[(3-Chloro-4-methoxyphenyl)methyl]amino]-6-cyanoquinoline-3-carboxylic acid pentafluorophenyl ester 

Relevant articles and documents

Quinolines as extremely potent and selective PDE5 inhibitors as potential agents for treatment of erectile dysfunction

In a continuing effort to discover novel chemotypes as potent and selective PDE5 inhibitors for the treatment of male erectile dysfunction (ED), we have found that 4-benzylaminoquinoline derivatives are very potent and selective PDE5 inhibitors. Some compounds in this series had PDE5 IC 50's as low as 50 pM. While an electron withdrawing group at the C6-position of the quinoline substantially improved PDE5 potency, an ethyl group at the C8-position not only improved the PDE5 potency but also the isozyme selectivity. Substitutents at the C3-position can incorporate a variety of different groups. The synthesis and primary structure-activity relationship of this new series of potent PDE5 inhibitors are described.