4039-92-3

Basic information

• Product Name: 1-(ChloroMethyl)-4-phenoxybenzene
• Synonyms: Benzene, 1-(chloromethyl)-4-phenoxy-
• CAS NO: 4039-92-3
• Molecular Formula: C₁₃H₁₁ClO
• Molecular Weight: 218.67884
• Mol File: 4039-92-3.mol
• Article Data: 18

Chemical Properties

• Appearance: /
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• CAS DataBase Reference: 1-(ChloroMethyl)-4-phenoxybenzene(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(ChloroMethyl)-4-phenoxybenzene(4039-92-3)
• EPA Substance Registry System: 1-(ChloroMethyl)-4-phenoxybenzene(4039-92-3)

Safety Data

• Hazardous Substances Data: 4039-92-3(Hazardous Substances Data)

Usage

General Description

1-(Chloromethyl)-4-phenoxybenzene is an organic chemical compound that has a unique structural formula that includes a phenyl group, a phenoxy group, and a chloromethyl group. It exists as a colorless or light yellow liquid at room temperature and may have a characteristic odor. 1-(ChloroMethyl)-4-phenoxybenzene is classified among the organochlorine compounds due to its composition that includes chlorine. It is often used in organic synthesis and pharmaceutical research due to its reactivity. Its reactivity comes majorly from the chloro-methyl group that could initiate various chemical reactions. However, handling this chemical requires caution due to its potential toxicity.

Upstream product

• 50-00-0 formaldehyd 
• 101-84-8 diphenylether 
• 2215-78-3 (4-phenoxyphenyl)methanol 
• 67-36-7 4-phenoxy benzaldehyde 
• 5031-78-7 4-phenoxyacetophenone 
• 21218-94-0 methyl 4-phenoxybenzoate 
• 2215-77-2 4-Phenoxybenzoic acid 

Downstream Products

• 5728-52-9 (4-biphenylyl)acetic acid 
• 92163-15-0 1-cyanomethyl-4-phenoxybenzene 
• 19444-26-9 α-Hydroxy-isobuttersaeure-p-phenyloxy-benzylester 
• 67-36-7 4-phenoxy benzaldehyde 
• 2215-90-9 4-Methoxymethyl-diphenylether 
• 93496-93-6 3,3,3-Trifluoro-2-methyl-2-(4-phenoxy-benzyloxy)-propionic acid methyl ester 
• 79807-99-1 C₁₉H₁₅NO₄ 
• 73909-02-1 4-phenoxy-benzyl thiocyanate 
• 380424-14-6 1-(4-phenoxy-benzyl)-piperidine-4-carboxylic acid amide 
• 655243-88-2 3-chloro-5,6-bis-(4-phenoxy-benzyloxy)-benzo[b]thiophene-2-carboxylic acid methyl ester 
• 19444-27-0 Methacrylsaeure-p-phenyloxy-benzylester 
• 380424-68-0 1-(4-phenoxy-benzyl)-piperidin-4-ylamine 
• 380426-07-3 (2-chloro-9-cyclopentyl-9H-purin-6-yl)-[1-(4-phenoxy-benzyl)-piperidin-4-yl]-amine 
• 79808-11-0 3-(4-Phenoxy-benzyloxy)-phenylamine 

Relevant articles and documents

Mechanism of solvolysis of substituted benzyl chlorides in aqueous ethanol

The mechanism of solvolyses of activated ortho-, meta- and para-substituted benzyl chlorides in aqueous ethanol has been studied by using the Hammett-Brown and Yukawa-Tsuno treatments as well as by correlating logarithms of solvolysis rate constants with relative stabilities of corresponding benzyl carbocations in water calculated at the IEFPCM-M06–2X/6-311+G(3df,3pd) level of theory. Benzyl chlorides containing strong conjugative electron-donors in the para-position solvolyze by the SN1 mechanism, whereas other activated benzyl chlorides solvolyze by the SN2 mechanism via loose transition states.

Halogenation through Deoxygenation of Alcohols and Aldehydes

An efficient reagent system, Ph3P/XCH2CH2X (X = Cl, Br, or I), was very effective for the deoxygenative halogenation (including fluorination) of alcohols (including tertiary alcohols) and aldehydes. The easily available 1,2-dihaloethanes were used as key reagents and halogen sources. The use of (EtO)3P instead of Ph3P could also realize deoxy-halogenation, allowing for a convenient purification process, as the byproduct (EtO)3Pa?O could be removed by aqueous washing. The mild reaction conditions, wide substrate scope, and wide availability of 1,2-dihaloethanes make this protocol attractive for the synthesis of halogenated compounds.

Method for Producing Benzyl Ester 2-aminonicotinicotinate Derivative

The present invention refers to 2-amino nicotinic for high yield derivatives of benzil ester, provides method that produces in high yield a. Benzyl halide derivatives a predetermined base 2-amino nicotinic acid derivative polar solvent during by the pres