404-17-1

Basic information

• Product Name: Acetamide, 2,2-difluoro-N-phenyl-
• CAS NO: 404-17-1
• Molecular Formula: C8H7F2NO
• Molecular Weight: 171.146
• Mol File: 404-17-1.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: Acetamide, 2,2-difluoro-N-phenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: Acetamide, 2,2-difluoro-N-phenyl-(404-17-1)
• EPA Substance Registry System: Acetamide, 2,2-difluoro-N-phenyl-(404-17-1)

Safety Data

• Hazardous Substances Data: 404-17-1(Hazardous Substances Data)

Upstream product

• 27074-47-1 N-Trifluorvinylacetanilid 
• 55-21-0 benzamide 
• 65864-64-4 trimethyl(difluoromethyl)silane 
• 103-71-9 phenyl isocyanate 
• 454-31-9 ethyl difluoroacetate 
• 62-53-3 aniline 
• 116-14-3 polytetrafluoroethylene 
• 381-73-7 Difluoroacetic acid 

Downstream Products

• 365-19-5 difluoro-acetic acid-(N-methyl-anilide) 

Relevant articles and documents

Hypervalent Iodine Reagent-Promoted Hofmann-Type Rearrangement/Carboxylation of Primary Amides

A novel transformation of primary amides to secondary amides promoted by hypervalent iodine reagents was developed. The hypervalent iodine reagent-mediated Hofmann-type rearrangement generated an isocyanate intermediate, which was subsequently trapped by an in situ generated carboxylic acid from the hypervalent iodine reagent to provide the corresponding secondary amides. This method provided a facile and efficient route for the synthesis of secondary amides from primary amides and also revealed novel reactivities of hypervalent iodine reagents.

Overcoming inaccessibility of fluorinated imines-synthesis of functionalized amines from readily available fluoroacetamides

Although imines are convenient substrates for the synthesis of functionalized amines, they may be hard to obtain, as in the case of fluorinated imines. To aid in overcoming this issue, we propose a protocol of corresponding amine synthesis from simple fluoroacetic acid-derived amides using Schwartz's reagent.