4045-03-8

Basic information

• Product Name: 2-THIOPHEN-2-YL-IMIDAZO[1,2-A]PYRIDINE
• Synonyms: 2-THIOPHEN-2-YL-IMIDAZO[1,2-A]PYRIDINE;BUTTPARK 20\01-91;2-Thien-2-ylimidazo[1,2-a]pyridine;(thienyl-2)-2 imidazopyridine
• CAS NO: 4045-03-8
• Molecular Formula: C₁₁H₈N₂S
• Molecular Weight: 200.26
• Mol File: 4045-03-8.mol
• Article Data: 40

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-THIOPHEN-2-YL-IMIDAZO[1,2-A]PYRIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-THIOPHEN-2-YL-IMIDAZO[1,2-A]PYRIDINE(4045-03-8)
• EPA Substance Registry System: 2-THIOPHEN-2-YL-IMIDAZO[1,2-A]PYRIDINE(4045-03-8)

Safety Data

• Hazardous Substances Data: 4045-03-8(Hazardous Substances Data)

Usage

General Description

2-Thiophen-2-yl-imidazo[1,2-a]pyridine is a chemical compound with a heterocyclic structure containing a thiophene ring fused to an imidazo-pyridine core. It is commonly used as a building block in the synthesis of pharmaceuticals and organic compounds due to its ability to modify and enhance specific functions within these molecules. 2-THIOPHEN-2-YL-IMIDAZO[1,2-A]PYRIDINE may exhibit pharmacological properties that are beneficial for the treatment of various diseases and medical conditions. Its unique structure and reactivity make it a valuable tool for drug discovery and development in the pharmaceutical industry.

Upstream product

• 504-29-0 2-aminopyridine 
• 29683-77-0 2-chloro-1-(thiophen-2-yl)ethanone 
• 4043-76-9 5-(3-bromo-imidazo[1,2-a]pyridin-2-yl)-thiophene-2-carboxylic acid 
• 10531-41-6 2-Bromoacetylthiophene 
• 98-03-3 thiophene-2-carbaldehyde 
• 88-15-3 2-Acetylthiophene 
• 4192-32-9 2-bromo-1-(5-methoxycarbonylthiophen-2-yl)-ethanone 
• 4101-82-0 5-imidazo[1,2-a]pyridin-2-yl-thiophene-2-carboxylic acid methyl ester 
• 4256-18-2 5-(3-bromo-imidazo[1,2-a]pyridin-2-yl)-thiophene-2-carboxylic acid methyl ester 
• 81447-27-0 2-tosyloxy-1-(2-thiophenyl)ethanone 
• 4298-52-6 2-ethynyl-thiophene 
• 110-86-1 pyridine 
• 307320-18-9 C₈H₈N₄S 
• 298229-64-8 1‐(thiophen‐2‐yl)ethanone oxime acetate 

Downstream Products

• 1609583-51-8 3-((4-chlorophenyl)thio)-2-(thiophen-2-yl)imidazo[1,2-a]pyridine 
• 1609583-41-6 3-(phenylthio)-2-(thiophen-2-yl)imidazo[1,2-a]pyridine 

Relevant articles and documents

A multi pathway coupled domino strategy: I2/ TBHP-promoted synthesis of imidazopyridines and thiazoles via sp3, sp2 and sp C-H functionalization

I2/TBHP-promoted, one-pot, multi pathway synthesis of imidazopyridines and thiazoles has been achieved through readily available ethylarenes, ethylenearenes and ethynearenes. I2/TBHP as an initiator and oxidant is used to realize the C-H functionalization of this domino reaction. Simple and available starting materials, wide range of functional group tolerance, high potential for drug activity of the products and application in production are the advantageous features of this method.

Synthetic method of imidazopyridine compounds

The invention provides a novel method for synthesizing imidazopyridine compounds. According to the invention, aminopyridine compounds and sulfur ylide are used as original reaction substrates, iron phthalocyanine (FeIIPc) is used as a catalyst, and a series of the imidazopyridine compounds are obtained under the condition that the advantages of mildness, greenness, high efficiency, wide substrateuniversality and the like are achieved.

Molecular iodine enabled generation of iminyl radicals from oximes: A facile route to imidazo[1,2-a]pyridines and its regioselective C-3 sulfenylated products from simple pyridines

An iodine promoted simple and environment friendly protocol has been developed to access imidazo[1,2-a]pyridines from unfunctionalized pyridines and oxime esters. This straightforward method efficiently converts the substrates into corresponding products affording moderate to good yields with large functional group tolerance. Additionally extensive investigation revealed that regioselective domino C-3 methyl sulfenylated imidazo[1,2-a]pyridines were also accessible first time from pyridines and oxime esters in DMSO solvent. The reaction operates through metal-free generation of iminyl radicals from easily accessible oxime esters, to build up the second heterocyclic ring on pyridines.