404567-14-2

Basic information

• Product Name: 1,4-anhydro-2-deoxy-1-C-[4-[[2-[2-[[4-[(1E)-2-phenylethenyl]phenyl]methoxy]ethoxy]ethoxy]methyl]phenyl]-D-erythro-pentitol
• Synonyms: 1,4-anhydro-2-deoxy-1-C-[4-[[2-[2-[[4-[(1E)-2-phenylethenyl]phenyl]methoxy]ethoxy]ethoxy]methyl]phenyl]-D-erythro-pentitol
• CAS NO: 404567-14-2
• Molecular Weight: 504.623
• Mol File: 404567-14-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1,4-anhydro-2-deoxy-1-C-[4-[[2-[2-[[4-[(1E)-2-phenylethenyl]phenyl]methoxy]ethoxy]ethoxy]methyl]phenyl]-D-erythro-pentitol(CAS DataBase Reference)
• NIST Chemistry Reference: 1,4-anhydro-2-deoxy-1-C-[4-[[2-[2-[[4-[(1E)-2-phenylethenyl]phenyl]methoxy]ethoxy]ethoxy]methyl]phenyl]-D-erythro-pentitol(404567-14-2)
• EPA Substance Registry System: 1,4-anhydro-2-deoxy-1-C-[4-[[2-[2-[[4-[(1E)-2-phenylethenyl]phenyl]methoxy]ethoxy]ethoxy]methyl]phenyl]-D-erythro-pentitol(404567-14-2)

Safety Data

• Hazardous Substances Data: 404567-14-2(Hazardous Substances Data)

Upstream product

• 404567-13-1 1,4-anhydro-2-deoxy-1-C-[4-[(methoxymethoxy)methyl]phenyl]-3,5-O-[1,1,3,3-tetrakis(1-methylethyl)-1,3-disiloxanediyl]-D-erythro-pentitol 
• 329767-69-3 1,4-anhydro-2-deoxy-1-C-[4-(hydroxymethyl)phenyl]-3,5-O-[1,1,3,3-tetrakis(1-methylethyl)-1,3-disiloxanediyl]-D-erythro-pentitol 
• 329767-72-8 11-[4-[(1E)-2-phenylethenyl]phenyl]-2,4,7,10-tetraoxaundecane 
• 329767-73-9 2-[2-[[4-[(1E)-2-phenylethenyl]phenyl]methoxy]ethoxy]ethanol 
• 130534-91-7 1-bromo-4-[(methoxymethyloxy)methyl]benzene 
• 101093-37-2 trans-4-stilbenemethanol 
• 150253-59-1 trans-4-chloromethylstilbene 
• 873-75-6 4-bromobenzenemethanol 
• 329767-70-6 1,4-anhydro-2-deoxy-1-C-[4-[[2-[2-[[4-[(1E)-2-phenylethenyl]phenyl]methoxy]ethoxy]ethoxy]methyl]phenyl]-3,5-O-[1,1,3,3-tetrakis(1-methylethyl)-1,3-disiloxanediyl]-D-erythro-pentitol 

Relevant articles and documents

Preparation of stilbene-tethered nonnatural nucleosides for use with blue-fluorescent antibodies

The synthesis of the first examples of stilbene-tethered hydrophobic C-nucleosides is described. Compounds of this type are targeted for use with our recently reported "blue-fluorescent antibodies with the aim of probing native and nonnatural DNA. The nucleophilic addition of aryl Grignard reagents to either a protected 2′-deoxy-1′-chloro-ribofuranose or a protected 2′-deoxy-ribonolactone was the key synthetic step and afforded C-nucleosides in good yields. Both routes resulted in a final product that was ≥ 90% of the β-anomer. Amide- and ether-based linkers for attachment of trans-stilbene to the nucleobase were assessed for utility during synthesis and in binding of the ligands to a blue-fluorescent monoclonal antibody. X-ray structures of each complex were obtained and serve as a guideline for second-generation stilbene-tethered C-nucleosides. The development of these hydrophobic nucleosides will be useful in current native and nonnatural DNA studies and invaluable for investigations regarding novel, nonnatural genomes in the future.