40478-12-4

Basic information

• Product Name: Benzamide, N-(hydroxymethyl)-4-nitro-
• CAS NO: 40478-12-4
• Molecular Formula: C8H8N2O4
• Molecular Weight: 196.163
• Mol File: 40478-12-4.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: Benzamide, N-(hydroxymethyl)-4-nitro-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzamide, N-(hydroxymethyl)-4-nitro-(40478-12-4)
• EPA Substance Registry System: Benzamide, N-(hydroxymethyl)-4-nitro-(40478-12-4)

Safety Data

• Hazardous Substances Data: 40478-12-4(Hazardous Substances Data)

Upstream product

• 61652-88-8 N-(Benzoyl-oxymethyl)-4-nitrobenzamid 
• 50-00-0 formaldehyd 
• 619-80-7 4-nitrobenzamide 

Downstream Products

• 619-80-7 4-nitrobenzamide 
• 61652-88-8 N-(Benzoyl-oxymethyl)-4-nitrobenzamid 
• 40478-20-4 Bis-(2,2'-dichloroethyl)aminomethyl-4-nitrobenzoesaeureamid 
• 67881-41-8 N-Chloromethyl-4-nitro-benzimidoyl chloride 
• 25642-82-4 N-Chlormethyl-4-nitro-benzamid 

Relevant articles and documents

Application of chiral triazole-substituted iodoarenes in the enantioselective construction of spirooxazolines

A catalytic highly enantioselective synthesis of spirooxazolines is presented. Starting from readily available 2-naphthol-substituted benzamides and using catalytic amounts of a chiral triazole-substituted iodoarene catalyst, a variety of spirooxazolines

Rate of formation of N-(hydroxymethyl)benzamide derivatives in water as a function of pH and their equilibrium constants

The third-order rate constants for the pH-dependent formation of the carbinolamides generated from the reaction of formaldehyde and benzamide, 4-chloro, 4-nitro, 4-methyl and 4-methoxybenzamide, are reported. The acid-catalyzed reaction was found to occur via rate-limiting proton transfer, whereas the hydroxide-dependent reaction occurred via a specific-base process. Coupling the rate constants for carbinolamide formation reported herein with the previously established rates for carbinolamide breakdown yielded equilibrium constants for the carbinolamides studied in water.

Solvent-free N-hydroxymethylation using formalin over basic alumina

A convenient and high yield method for N-hydroxymethylation of amines with formalin over basic alumina under solvent-free conditions with microwave heating is described.