404909-86-0Relevant articles and documents
Kinetic control of proline amide rotamers: Total synthesis of trans,trans- and cis,cis-ceratospongamide
Deng, Shaojiang,Taunton, Jack
, p. 916 - 917 (2007/10/03)
Ceratospongamide is a cyclic peptide natural product that is biosynthesized as a mixture of two proline rotamers. Remarkably, these rotamers do not detectably interconvert at temperatures up to 100 °C. Here we report high-yielding syntheses of each rotame