40492-24-8 Usage
General Description
5-Pyrimidinamine, N-methyl- (9CI) is a chemical compound classified under the family of pyrimidines and piperedinediones. Its systematic name is N-methylpyrimidin-5-amine, indicating it contains both a pyrimidinamine structure and a methyl group. Owing to its chemical configuration, it is an organic compound and contains the elements of carbon, hydrogen, and nitrogen. This chemical compound is widely used in the pharmaceutical and medical industry, often serving as a building block or intermediate for more complex compounds. Information regarding its toxicity or potential effects on health is quite scarce, therefore it should be handled with caution until more comprehensive studies are available.
Check Digit Verification of cas no
The CAS Registry Mumber 40492-24-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 4,0,4,9 and 2 respectively; the second part has 2 digits, 2 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 40492-24:
(7*4)+(6*0)+(5*4)+(4*9)+(3*2)+(2*2)+(1*4)=98
98 % 10 = 8
So 40492-24-8 is a valid CAS Registry Number.
40492-24-8Relevant articles and documents
P(III)/P(V)-Catalyzed Methylamination of Arylboronic Acids and Esters: Reductive C-N Coupling with Nitromethane as a Methylamine Surrogate
Li, Gen,Qin, Ziyang,Radosevich, Alexander T.
supporting information, p. 16205 - 16210 (2020/10/26)
The direct reductive N-arylation of nitromethane by organophosphorus-catalyzed reductive C-N coupling with arylboronic acid derivatives is reported. This method operates by the action of a small ring organophosphorus-based catalyst (1,2,2,3,4,4-hexamethylphosphetane P-oxide) together with a mild terminal reductant hydrosilane to drive the selective installation of the methylamino group to (hetero)aromatic boronic acids and esters. This method also provides for a unified synthetic approach to isotopically labeled N-methylanilines from various stable isotopologues of nitromethane (i.e., CD3NO2, CH315NO2, and 13CH3NO2), revealing this easy-to-handle compound as a versatile precursor for the direct installation of the methylamino group.
