405-39-0

Basic information

• Product Name: Z-LYS(Z)-OH
• Synonyms: DI-N-CBZ-L-LYSINE;DICARBOBENZOXY-L-LYSINE;Z-LYSINE(Z)-OH;Z-LYS(Z)-OH;N-ALPHA,EPSILON-BIS-Z-L-LYSINE;N-ALPHA,N-EPSILON-DI-Z-L-LYSINE;N-ALPHA, N-EPSILON-DIBENZYLOXYCARBONYL-L-LYSINE;N-ALPHA-N-EPSILON-DICARBOBENZOXY-L-LYSINE
• CAS NO: 405-39-0
• Molecular Formula: C₂₂H₂₆N₂O₆
• Molecular Weight: 414.45
• EINECS: 206-971-9
• Product Categories: Amino Acid Derivatives;Amino Acids & Derivatives;Aromatics;Intermediates;peptides
• Mol File: 405-39-0.mol
• Article Data: 16

Chemical Properties

• Melting Point: 76-78°C
• Boiling Point: 659 °C at 760 mmHg
• Flash Point: 352.4 °C
• Appearance: White solid
• Density: 1.238 g/cm³
• Vapor Pressure: 2.9E-18mmHg at 25°C
• Refractive Index: 1.568
• Storage Temp.: Store at RT.
• Solubility: DMSO (Slightly), Methanol (Slightly)
• PKA: 3.97±0.21(Predicted)
• BRN: 1897206
• CAS DataBase Reference: Z-LYS(Z)-OH(CAS DataBase Reference)
• NIST Chemistry Reference: Z-LYS(Z)-OH(405-39-0)
• EPA Substance Registry System: Z-LYS(Z)-OH(405-39-0)

Safety Data

• WGK Germany: 3
• Hazardous Substances Data: 405-39-0(Hazardous Substances Data)

Usage

Chemical Properties

White Solid

Uses

Protected L-lysine

InChI:InChI=1/C22H26N2O6/c25-20(26)19(24-22(28)30-16-18-11-5-2-6-12-18)13-7-8-14-23-21(27)29-15-17-9-3-1-4-10-17/h1-6,9-12,19H,7-8,13-16H2,(H,23,27)(H,24,28)(H,25,26)/t19-/m0/s1

Upstream product

• 55592-84-2 Nε-Cbz-lysine 
• 56-87-1 L-lysine 
• 501-53-1 benzyl chloroformate 
• 5335-05-7 chloromethyl benzoate 
• 21160-82-7 4-nitrophenyl N₂,N₆-bis[(phenylmethoxy)carbonyl]-L-lysinate 
• 144889-39-4 N₂,N₆-bis(benzyloxycarbonyl)lysine tert-butyl ester 
• 657-27-2 L-Lysine hydrochloride 
• 19506-72-0 benzyl-8-quinolyl carbonate 
• 63842-04-6 sodium benzyloxycarbonyl thiosulfate 
• 32279-04-2 (p-hydroxyphenyl)dimethylsulfonium methyl sulfate 
• 1155-64-2 N₆-[(benzyloxy)carbonyl]-L-lysine 
• 24498-31-5 (S)-methyl 2-amino-6-(benzyloxycarbonylamino)hexanoate 
• 923-27-3 D-lysine 
• 13139-17-8 N-(Benzyloxycarbonyloxy)succinimide 

Downstream Products

• 106386-19-0 N^α-(N²,N⁶-bis-benzyloxycarbonyl-L-lysyl)-N^ω-nitro-L-arginine methyl ester 
• 911664-89-6 Z-Lys(Z)-Gly-OMe 
• 17460-95-6 N-(N²,N⁶-bis-benzyloxycarbonyl-L-lysyl)-L-valine 
• 120176-22-9 N⁶-[N^2',N^6'-di(benzyloxycarbonyl)-L-lysyl]-L-lysine 
• 53613-40-4 N-(N²,N⁶-bis-benzyloxycarbonyl-L-lysyl)-L-tyrosine ethyl ester 
• 91307-61-8 N-(N²,N⁶-bis-benzyloxycarbonyl-L-lysyl)-L-tyrosine benzyl ester 
• 146754-64-5 benzyl N₆-((benzyloxy)carbonyl)-N₂-(N₂,N₆-bis((benzyloxy)carbonyl)-L-lysyl)-L-lysinate 
• 74283-31-1 di-Z-L-lysine hydrazide 
• 27894-50-4 methyl (2S)-2-amino-6-{[(benzyloxy)carbonyl]amino}hexanoate hydrochloride 
• 1676-86-4 N-benzyloxycarbonyl-L-lysine N-carboxyanhydride 
• 55461-90-0 N-(N²,N⁶-bis-benzyloxycarbonyl-lysyl)-N'-isonicotinoyl-hydrazine 
• 52126-91-7 Z(OMe)-Lys(Z)-Tyr-OMe 
• 195526-65-9 N-(N²,N⁶-bis-benzyloxycarbonyl-L-lysyl)-L-tyrosine amide 
• 13567-34-5 N_α,N_ξ-di-Cbz-L-lysylglycine ethyl ester 

Relevant articles and documents

DRUG-LOADED EMULSION

The present invention relates to a drug-loaded emulsion, comprising a modified hydrophobic excipient having the following formula, a hydrophobic drug and a surfactant: where R is a hydrophobic natural compound or a hydrophobic synthetic compound with one to three hydroxyl groups (n=1-3); and R1 is an α-amino protecting group, and R2 is an amino acid side chain, wherein, when m=0, R is reacted with an amino acid derivative with a protecting group by esterification to form a hydrophobic excipient carrying the amino acid derivative with a protecting group; or when m=1, R is firstly introduced with an amino acid linking arm of different chain lengths (l=1, 2, 4, 6) via an ester group, and then introduced with an amino acid derivative with a protecting group.

CONJUGATES COMPRISING SELF-IMMOLATIVE GROUPS AND METHODS RELATED THERETO

In some aspects, the invention relates to an antibody-drug conjugate, comprising an antibody; a linker; and an active agent. The antibody-drug conjugate may comprise a self- immolative group. The linker may comprise an O-substituted oxime, e.g., wherein the oxygen atom of the oxime is substituted with a group that covalently links the oxime to the active agent; and the carbon atom of the oxime is substituted with a group that covalently links the oxime to the antibody.

A novel double-amino of the phosphorylcholine compound Lys - EG - PC and its preparation method (by machine translation)

The invention discloses a novel double-amino of the phosphorylcholine compound Lys - EG - PC and its preparation method. The purpose of this invention is to provide a can be used for surface treatment agent or surface treating agent raw material substance of the phosphorylcholine compound, such compounds can also be directly used as the modifier, a chain extender or cross-linking agent used for to various substrate to modify the surface of the substrate or modified, so as to improve the blood compatibility of the high molecular material, reduce protein adsorption, reduce cell precipitation, in tissue engineering, controlled drug delivery, gene therapy, in the field of cosmetics and the like has a great Academic value and broad application prospects. The step is simple, easy to operate, and the practicability is strong. (by machine translation)