40512-56-9

Basic information

• Product Name: BOC-(S)-2-THIENYLGLYCINE
• Synonyms: BOC-(S)-2-THIENYLGLYCINE;(S)-TERT-BUTOXYCARBONYLAMINO-THIOPHEN-2-YL-ACETIC ACID;Boc-(S)-2-(2-Thienyl)-glycine;(alphaS)-alpha-[[(tert-Butoxy)carbonyl]amino]-2-thiopheneacetic acid;(S)-alpha-[[(1,1-Dimethylethoxy)carbonyl]amino]-2-thiopheneacetic acid;(S-2-(tert-butoxycarbonylaMino)-2-(thiophen-2-yl)acetic acid;(S)-a-(Boc-amino)-2-thiopheneacetic acid;Boc-(S)-2-thienylglycine≥ 98% (HPLC, Chiral purity)
• CAS NO: 40512-56-9
• Molecular Formula: C₁₁H₁₅NO₄S
• Molecular Weight: 257.31
• Product Categories: Unusual amino acids
• Mol File: 40512-56-9.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 421.3 °C at 760 mmHg
• Flash Point: 208.6 °C
• Appearance: /
• Density: 1.273
• Storage Temp.: 2-8°C
• BRN: 5872840
• CAS DataBase Reference: BOC-(S)-2-THIENYLGLYCINE(CAS DataBase Reference)
• NIST Chemistry Reference: BOC-(S)-2-THIENYLGLYCINE(40512-56-9)
• EPA Substance Registry System: BOC-(S)-2-THIENYLGLYCINE(40512-56-9)

Safety Data

• WGK Germany: 3
• Hazardous Substances Data: 40512-56-9(Hazardous Substances Data)

Usage

Chemical Properties

Colorless oil

Upstream product

• 21124-40-3 D,L-(2-thienyl)glycine 
• 24424-99-5 di-tert-butyl dicarbonate 
• 98-03-3 thiophene-2-carbaldehyde 
• 4248-19-5 tert-butyl carbazate 
• 124-38-9 carbon dioxide 
• 479423-34-2 N-Boc-α-(phenylsulfonyl)-α-(thiophen-2-yl)methylamine 
• 1291065-87-6 C₂₂H₄₁NO₂SSn 

Downstream Products

• 869558-00-9 ter-t-butyl 2-{[3-(cyclohexylcarbonyl)pyridin-2-yl]amino}-2-oxo-1-thien-2-ylethylcarbamate 
• 869558-52-1 tert-buty 2-{[3-(4-fluorobenzoyl)pyridin-2-yl] amino}-2-oxo-1-thien-2-ylethylcarbamate 
• 1132660-29-7 C₂₄H₂₄N₂O₄S 
• 1379514-57-4 (3R)-3-(2-(tert-butoxycarbonylamino)-2-(thiophen-2-yl)acetoxy)-1-(2-oxo-2-phenylethyl)-1-azoniabicyclo[2.2.2]octane chloride 

Relevant articles and documents

Synthesis of arylglycine and mandelic acid derivatives through carboxylations of α-amido and α-acetoxy stannanes with carbon dioxide

Incorporation reactions of carbon dioxide (CO2) with N-Boc-α-amido and α-acetoxy stannanes were developed using CsF as a mild tin activator. Monoprotected α-amido stannanes could be used, and the corresponding arylglycine derivatives were obtained in moderate-to-high yields under 1 MPa (10 atm) of CO2 pressure. α-Acetoxy stannanes also underwent carboxylation to afford mandelic acid derivatives in excellent yields under ambient CO2 pressure. Both transformations enabled the synthesis of α-tertiary and α-quaternary carboxylic acid derivatives. In addition, the chirality of (S)-N-tert-butylsulfonyl-α- amido stannanes was transferred with up to 90% inversion of configuration at 100 °C.

UREA DERIVATIVE, PROCESS FOR PRODUCING THE SAME, AND USE

The present invention provides a urea derivative or a salt thereof, which is useful as a therapeutic agent for thrombosis. The derivative is represented by Formula (I): [Chemical formula I] wherein Cy is an aromatic hydrocarbon group which may be substituted or an aromatic heterocyclic group which may be substituted; R1 is a hydrogen atom or a hydrocarbon group which may be substituted; V is -C(O)-, -S(O)-, or -S(O)2-; W is -N(R2)-, -O-, or a bond (wherein R2 is a hydrogen atom or a hydrocarbon group which may be substituted); X is alkylene which may be substituted; Y is -C(O)-, -S(O)-, or -S(O)2-; Z is a bond, a chain hydrocarbon group which may be substituted, or -N=; ring A is a non-aromatic nitrogen-containing heterocyclic ring which may be substituted; ring B is a nitrogen-containing heterocyclic ring which may be substituted; and [Chemical formula 2]------￣?,?------? are each independently a single bond or a double bond; provided that R1 may be bonded to R2 to form a non-aromatic nitrogen-containing heterocyclic ring and that R2 may be bonded to a substituent of X to form a non-aromatic nitrogen-containing heterocyclic ring which may be substituted.