4052-92-0Relevant articles and documents
A New Amphiphilic Br?nsted Acid as Catalyst for the Friedel–Crafts Reactions of Indoles in Water
Cheng, Yuan,Ou, Xiongyu,Ma, Jimei,Sun, Linhao,Ma, Zhong-Hua
, p. 66 - 72 (2019/01/04)
A new amphiphile 1a featuring with two -NHSO2C4F9 sites is designed and synthesized as Br?nsted diacid. The amphiphilicity arose from nano-aggregations of hydrophobic fluorocarbon chains and extension of hydrophilic NH groups, confirmed by Tyndall effect and TEM. The acidity of 1a rivals to concentrated H2SO4, examined by the Hammett acidity function, 31P NMR and conductance titration. Compound 1a demonstrated excellent catalytic performance in the Friedel–Crafts alkylation of indoles in water. Reactive substrates, such as β-monosubstituted vinyl ketones in 1,4-addition and aldehydes in condensation, were quantitatively converted, and the products were easily isolated by filtration or extraction in 85–96 % yields. Additionally, there was no observation of effect of the acidity weakening of 1a on catalysis when poor-reactive substrates were used, such as β,β-disubstituted vinyl ketones in 1,4-addition and ketones in condensation. The two kinds of reactions were practised very smoothly. The formed nano-aggregations and the strong acidity of 1a were responsible for the highly efficient aqueous catalysis. Notably, 1a was recycled at least 3 times thanks to its amphiphilic structure. It was demonstrated the nano-aggregations played a key role in the aqueous synthesis.
METHOD FOR PRODUCING DICARBOXYLIC ACID COMPOUND
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Paragraph 0177; 0180, (2018/06/09)
It is an object of the present invention to provide an excellent method for producing an excellent therapeutic agent. The solution of the present invention is as shown in the following scheme: wherein R1 represents a C1-C6 alkyl group, R2 represents a C1-C6 alkyl group, and R3 represents a C1-C6 alkyl group.
Nitrogen-containing heterocycle derivatives and applications thereof
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Paragraph 0223-0225, (2018/03/24)
The invention discloses nitrogen-containing heterocycle derivatives and applications thereof, relates to compounds of a general formula (V), a preparing method thereof and applications of the compounds in medicines, and more particularly relates to compound derivatives of compounds shown as the general formula (V), a preparing method thereof and uses of the derivatives in medicines preventing andtreating hyperlipemia, hypercholesterolemia, hypertriglyceridemia, fatty degeneration of liver, diabetes mellitus type 2, hyperglycemia, obesity or insulin resistance and metabolic syndrome and resisting antitumor, with the derivatives being adopted as therapeutic agents. The compounds disclosed by the invention can also reduce total cholesterol, LDL-cholesterol and triglyceride, can increase liver LDL receptor expression, and inhibit PCSK9 expression.
