405224-25-1

Basic information

• Product Name: Butanamide, N-(5-bromo-1H-pyrazolo[3,4-b]pyridin-3-yl)-
• CAS NO: 405224-25-1
• Molecular Formula: C10H11BrN4O
• Molecular Weight: 283.128
• Mol File: 405224-25-1.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: Butanamide, N-(5-bromo-1H-pyrazolo[3,4-b]pyridin-3-yl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Butanamide, N-(5-bromo-1H-pyrazolo[3,4-b]pyridin-3-yl)-(405224-25-1)
• EPA Substance Registry System: Butanamide, N-(5-bromo-1H-pyrazolo[3,4-b]pyridin-3-yl)-(405224-25-1)

Safety Data

• Hazardous Substances Data: 405224-25-1(Hazardous Substances Data)

Upstream product

• 405224-23-9 5-bromo-2-chloropyridine-3-carbonitrile 
• 405224-22-8 5-bromo-2-oxo-1,2-dihydropyridine-3-carbonitrile 

Relevant articles and documents

A Casein kinase 1/Checkpoint kinase 1 pyrazolo-pyridine protein kinase inhibitor as novel activator of the p53 pathway

Reactivation of the wild-type p53 pathway is one key goal aimed at developing targeted therapeutics in the cancer research field. Although most p53 protein kinases form 'p53-activating' signals, there are few kinases whose action can contribute to the inhibition of p53, as Casein kinase 1 (CK1) and Checkpoint kinase 1 (CHK1). Here we report on a pyrazolo-pyridine analogue showing activity against both CK1 and CHK1 kinases that lead to p53 pathway stabilisation, thus having pharmacological similarities to the p53-activator Nutlin-3. These data demonstrate the emerging potential utility of multivalent kinase inhibitors.