40525-15-3Relevant articles and documents
CANNABIDIOL-TYPE CANNABINOID COMPOUND
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Paragraph 0040; 0042; 0043, (2021/05/29)
The present invention relates to a cannabidiol (CBD) type cannabinoid compound for use as a medicament. The CBD-type cannabinoid, 6-hydroxy cannabidiol (6-0 H CBD), is a metabolite of CBD. The cannabinoid can be produced by synthetic means and a method for the production of 6-0 H CBD is described herein. In addition, disclosed herein are data which demonstrate the efficacy of 6-0 H CBD in a model of disease.
POLYCANNABINOIDS, COMPOUNDS, COMPOSITIONS AND METHODS OF USE
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Paragraph 0166, (2021/10/22)
Polymers comprising a plurality of cannabinoids, methods of preparation thereof, and methods of use to treat a number of disease conditions are reported. Also provided are polymer coatings, films, fibers, and non-woven fabrics for a variety of topical app
Synthesis of CBD and Its Derivatives Bearing Various C4′-Side Chains with a Late-Stage Diversification Method
Gong, Xudong,Sun, Changliang,Abame, Melkamu Alemu,Shi, Wenqiang,Xie, Yuanchao,Xu, Wanbin,Zhu, Fuqiang,Zhang, Yan,Shen, Jingshan,Aisa, Haji A.
, p. 2704 - 2715 (2020/02/04)
A novel synthetic route for making (-)-CBD and its derivatives bearing various C4′-side chains is developed by a late-stage diversification method. Starting from commercially available phloroglucinol, the key intermediate (-)-CBD-2OPiv-OTf is efficiently and regioselectively prepared and further undergoes Negishi cross-coupling to furnish (-)-CBD. This approach allowed an efficient synthesis of (-)-CBD in a five-step total 52% yield on a 10 g scale. Furthermore, diversification on the C4′-side chain with this method can be realized in a wide range.