4055-39-4 Usage
Description
Mitomycin A, also known as the 6-methoxy analog of Mitomycin C, is an antitumor antibiotic belonging to the family of mitomycins. It is characterized by its red-violet crystal appearance and possesses both antibiotic and antitumor properties. However, it also exhibits a high level of toxicity.
Uses
Used in Pharmaceutical Industry:
Mitomycin A is used as an antitumor agent for its ability to inhibit tumor growth and progression. It is particularly effective against various types of cancer, including solid malignancies.
Used in Cancer Treatment:
Mitomycin A is used as a chemotherapy agent for its potent antitumor activity. It is often administered in combination with other chemotherapeutic drugs to enhance the overall treatment efficacy and overcome drug resistance in cancer patients.
Used in Research and Development:
Due to its unique chemical properties and high toxicity, Mitomycin A is also utilized in research and development for the study of its mechanism of action, potential applications, and the development of less toxic or more targeted therapies based on its structure and function.
Check Digit Verification of cas no
The CAS Registry Mumber 4055-39-4 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 4,0,5 and 5 respectively; the second part has 2 digits, 3 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 4055-39:
(6*4)+(5*0)+(4*5)+(3*5)+(2*3)+(1*9)=74
74 % 10 = 4
So 4055-39-4 is a valid CAS Registry Number.
4055-39-4Relevant articles and documents
Reaction of glycosyl halides with 7-hydroxy-9a-methoxymitosane sodium salt
Furuhata,Komiyama,Takeda,Takayanagi,Torii,Mishima,Ogura,Hata
, p. 2651 - 2654 (1989)
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Facile Nucleophilic Cleavage of Selenide with Dimedone. Synthesis of Novel 6-Demethylmitomycins
Arai, Hitoshi,Kasai, Masaji
, p. 4151 - 4152 (2007/10/02)
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7-(diphenylmethyl)oxy-9a-methoxymitosane
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, (2008/06/13)
7-(Diphenylmethyl)oxy-9a-methoxymitosane is a novel intermediate for conversion into 7-amino and 7-oxy-9a-methoxymitosanes and is also useful for inhibiting mammalian tumor growth. The compound is prepared by reacting 7-hydroxy-9a-methoxymitosane with diazodiphenylmethane. In a preferred reaction, the compound is prepared from mitomycin C via 7-hydroxy-9a-methoxymitosane without drying (water removal). The intermediate is advantageously converted to the very effective anti-tumor agent 7-[2-(4-nitrophenyldithio)ethylamino]-9a-methoxymitosane in unexpectedly high yields using a two step process where the first step constitutes conversion to 7-[2-(2-pyridyldithio)ethylamino]-9a-methoxymitosane or 7-[2-(3-nitro-2-pyridyldithio)ethylamino]-9a-methoxymitosane.