40564-60-1

Basic information

• Product Name: 5-oxo-6-phenylhexanoic acid
• Synonyms: 5-oxo-6-phenylhexanoic acid
• CAS NO: 40564-60-1
• Molecular Weight: 206.241
• Mol File: 40564-60-1.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 5-oxo-6-phenylhexanoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 5-oxo-6-phenylhexanoic acid(40564-60-1)
• EPA Substance Registry System: 5-oxo-6-phenylhexanoic acid(40564-60-1)

Safety Data

• Hazardous Substances Data: 40564-60-1(Hazardous Substances Data)

Upstream product

• 1921-90-0 2-benzylidenecyclopentanone 
• 108-55-4 glutaric anhydride, 
• 1589-82-8 phenylmagnesium bromide 
• 54723-26-1 methyl 6-phenyl-5-oxohexanoate 
• 100-44-7 benzyl chloride 
• 100-52-7 benzaldehyde 
• 25077-25-2 N-methyladipinimide 
• 29392-77-6 sodium 3-ethoxy-3-oxo-1-phenylprop-1-en-1-olate 
• 100609-21-0 5-Oxo-6-phenyl-hexansaeure-⁽¹⁾-methylamid 
• 858251-30-6 2-phenylacetyl-glutaric acid diethyl ester 

Downstream Products

• 305822-96-2 4H-Benzo[a]quinolizin-4-one, 1,2,3,6,7,11b-hexahydro-9-(phenylmethoxy)-11b-(phenylmethyl)- 
• 305822-95-1 4H-Benzo[a]quinolizin-4-one, 1,2,3,6,7,11b-hexahydro-9-hydroxy-11b-(phenylmethyl)- 
• 100258-98-8 δ-Hydroxy-ε-phenyl-capronsaeure-p-toluidid 
• 5581-75-9 6-phenylhexanic acid 

Relevant articles and documents

Activation of the hypervalent fluoroiodane reagent by hydrogen bonding to hexafluoroisopropanol

Hexafluoroisopropan-2-ol (HFIP) is an excellent solvent for promoting fluorinations with the hypervalent fluoroiodane reagent 1 and crucially, it removes the need for transition metals or TREAT-HF activators. The fluoroiodane reagent 1 was used in HFIP to monofluorinate 1,3-ketoesters and to fluorocyclise unsaturated carboxylic acids in excellent yields under mild reaction conditions.

Intramolecular fluorocyclizations of unsaturated carboxylic acids with a stable hypervalent fluoroiodane reagent

A new class of fluorinated lactones was prepared by the intramolecular fluorocyclizations of unsaturated carboxylic acids by using the stable fluoroiodane reagent in combination with AgBF4. This unique reaction incorporates a cyclization, an aryl migration, and a fluorination all in one step. The fluoroiodane reagent, prepared easily from fluoride, can also be used without a metal catalyst to give moderate yields within just 1 hour, thus demonstrating that it is a suitable reagent for developing new 18F-labelled radiotracers for PET imaging. All in one: A new class of lactones containing a tertiary alkyl fluoride was prepared in high yields by using a stable fluoroiodane reagent. This unique reaction incorporates a cyclization, an aryl migration, and a fluorination all in one step.