4057-61-8

Basic information

• Product Name: 1,2,5-Thiadiazole, 3,4-diphenyl-
• CAS NO: 4057-61-8
• Molecular Formula: C14H10N2S
• Molecular Weight: 238.313
• Mol File: 4057-61-8.mol
• Article Data: 9

Chemical Properties

• CAS DataBase Reference: 1,2,5-Thiadiazole, 3,4-diphenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 1,2,5-Thiadiazole, 3,4-diphenyl-(4057-61-8)
• EPA Substance Registry System: 1,2,5-Thiadiazole, 3,4-diphenyl-(4057-61-8)

Safety Data

• Hazardous Substances Data: 4057-61-8(Hazardous Substances Data)

Usage

Class

Organic heterocyclic compound

Subclass

1,2,5-thiadiazoles

Structure

Five-membered ring containing one sulfur atom, two nitrogen atoms, and two carbon atoms

Applications

Building block in the synthesis of pharmaceuticals, agrochemicals, and materials science

Versatility

Valuable intermediate for the production of various functional materials and bioactive compounds

Biological activities

Anti-cancer, anti-inflammatory, and anti-microbial properties

Potential

Promising target for drug discovery and development

Upstream product

• 4702-78-7 benzil dihydrazone 
• 23873-81-6 benzildioxime 
• 4057-62-9 3-phenyl-1,2,5-thiadiazole 
• 451-40-1 phenyl benzyl ketone 
• 886-38-4 diphenylcyclopropenone 
• 23431-14-3 3,4-diphenyl-1,2,5-thiadiazole 2-oxide 
• 134-81-6 benzil 
• 2227-79-4 benzenecarbothioamide 
• 88089-52-5 (Z)-((1,2-diphenylvinyl)oxy)trimethylsilane 
• 89929-37-3 3,5-diphenyl-1,4,2,6-dithiadiazine 
• 762-42-5 dimethyl acetylenedicarboxylate 
• 501-65-5 diphenyl acetylene 
• 5344-88-7 benzil monohydrazone 
• 5700-60-7 1,2-Diphenylethylenediamine 

Downstream Products

• 83392-70-5 3,4-Diphenyl-[1,2,5]telluradiazole 
• 668-94-0 4,5-diphenyl-1H-imidazole 

Relevant articles and documents

Unexpected production of 2,4,6-triphenyl-1,3,5-triazine in the electroreduction of 3,4-diphenyl-1,2,5-thiadiazole 1-oxide. Theoretical estimation of reactive sites for 1-oxide and 1,1-dioxide 1,2,5-thiadiazoles

3,4-Diphenyl-1,2,5-thiadiazole 1-oxide (1a) in acetonitrile solution is electroreduced to 2,4,6-triphenyl-1,3,5-triazine and 3,4-diphenyl-1,2,5- thiadiazole. This behavior is very different from that of similar compounds with other oxidation states of the

Reaction of trithiazyl trichloride with alkenes and alkynes

Alkenes and alkynes react readily with trithiazyl trichloride 1 to give 1,2,5-thiadiazoles 2 in one step. Thus 3-amino-1,2,5-thiadiazole 5 is now readily available from N-vinylphthalimide and 1 in two steps. Cyclic alkenes react similarly to give fused thiadiazoles (7, 12) and phenanthrene gives the phenanthrothiadiazole 16. Tetra-substituted alkenes such as 13 appear to give the analogous 3,4-dihydrothiadiazoles (e.g. 14) which spontaneously ring open to give readily hydrolysed bis(methyleneamino) sulfides (e.g. 15). A simple set of mechanisms is proposed for all of these reactions.

A-ALKYLATION, ALKENYLATION, AND ARYLATION OF 1,2,5-THIADIAZOLES

A new synthetic method of 1,2,5-thiadiazoles is reported, which affording mono- or disubstituted derivatives by one pot procedure, clarifies unknown aspects of the 1,2,5-thiadiazole ring reactivity.