405887-01-6

Basic information

• Product Name: Acetic acid, 2-[[2-[(1E)-2-[5-(aMinoiMinoMethyl)-2-hydroxyphenyl]ethenyl]-2,3-dihydro-5-[[1-(1-iMinoethyl)-4-piperidinyl]oxy]-1H-indol-1-yl]sulfonyl]-
• Synonyms: Acetic acid, 2-[[2-[(1E)-2-[5-(aMinoiMinoMethyl)-2-hydroxyphenyl]ethenyl]-2,3-dihydro-5-[[1-(1-iMinoethyl)-4-piperidinyl]oxy]-1H-indol-1-yl]sulfonyl]-;QEANYZQLUDFOKO-IEOJQXRNSA-N
• CAS NO: 405887-01-6
• Molecular Formula: C₂₆H₃₁N₅O₆S
• Molecular Weight: 541.61924
• Mol File: 405887-01-6.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Acetic acid, 2-[[2-[(1E)-2-[5-(aMinoiMinoMethyl)-2-hydroxyphenyl]ethenyl]-2,3-dihydro-5-[[1-(1-iMinoethyl)-4-piperidinyl]oxy]-1H-indol-1-yl]sulfonyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: Acetic acid, 2-[[2-[(1E)-2-[5-(aMinoiMinoMethyl)-2-hydroxyphenyl]ethenyl]-2,3-dihydro-5-[[1-(1-iMinoethyl)-4-piperidinyl]oxy]-1H-indol-1-yl]sulfonyl]-(405887-01-6)
• EPA Substance Registry System: Acetic acid, 2-[[2-[(1E)-2-[5-(aMinoiMinoMethyl)-2-hydroxyphenyl]ethenyl]-2,3-dihydro-5-[[1-(1-iMinoethyl)-4-piperidinyl]oxy]-1H-indol-1-yl]sulfonyl]-(405887-01-6)

Safety Data

• Hazardous Substances Data: 405887-01-6(Hazardous Substances Data)

Relevant articles and documents

Cinnamylindoline derivatives: Synthesis and factor Xa (FXa) inhibitory activities

A series of cinnamylindoline derivatives were synthesized, and their factor Xa (FXa) inhibitory activities and selectivity over trypsin were evaluated. Among them, some novel derivatives showed potent FXa inhibitory activities and good selectivity over trypsin. Especially, (E)-2-{5-[1-(acetimidoyl)piperidin-4- yloxy]-2-[2-(5-amidino-2-hydroxyphenyl)ethen-1-yl]indolin-1-ylsulfonyl}acetic acid (22f) having 2-hydroxycinnamyl moiety exhibited the most potent FXa inhibitory activity in vitro. Furthermore, 22f also exhibited potent anticoagulant activities in vitro.