40589-84-2Relevant articles and documents
One-pot, solvent-free access to unsymmetrical ureas by palladium-catalysed reductive alkylation using molecular hydrogen
Mohy El Dine, Tharwat,Chapron, Simon,Duclos, Marie-Christine,Duguet, Nicolas,Popowycz, Florence,Lemaire, Marc
, p. 5445 - 5454 (2013/09/02)
Palladium-catalysed reductive alkylation of monosubstituted ureas has been studied in the presence of aldehydes and using molecular hydrogen as a clean reductant. Unsymmetrical N,N′-disubstituted ureas were formed in good to excellent isolated yields (60-93 %) without the production of salt waste. This reaction was incorporated to a one-pot, solvent-free sequence involving the alkylation of monosubstituted ureas generated in situ from the corresponding amines. Unsymmetrical N,N′-disubstituted ureas were prepared in 60-93 % isolated yield by palladium-catalysed reductive alkylation of monosubstituted ureas using aldehydes as alkylating agents and molecular hydrogen as a clean reductant. A one-pot, solvent-free sequence was also developed from the corresponding amines. Copyright
SYNTHESIS OF ARYLMETHYLUREAS AND THE INFLUENCE OF STRUCTURE ON THEIR ANTISPASMODIC ACTIVITY
Bakibaev, A. A.,Tignibidina, L. G.,Filimonov, V. D.,Gorshkova, V. K.,Saratikov, A. S.,et al.
, p. 296 - 301 (2007/10/02)
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Some Extensions of von Braun (BrCN) Reaction on Organic Bases: Part II
Malik, Abdul,Afza, Nighat,Siddiqui, Salimuzzaman
, p. 512 - 518 (2007/10/02)
Extensions of von Braun Cyanogen bromide reaction on Ephedra alkaloids and simpler bases have resulted in synthesis of substituted oxazolidines and a whole series of nitrogen analogues of ephedrine, desoxy ephedrine and simpler amines.The general applicability and limitations of such extension of the reaction are also discussed. - Key words: von Braun Cyanogen Bromide Reaction
