405931-46-6

Basic information

• Product Name: 1-(1-Bromoethyl)-2-Fluorobenzene
• Synonyms: 1-(1-Bromoethyl)-2-Fluorobenzene
• CAS NO: 405931-46-6
• Molecular Formula: C₈H₈BrF
• Molecular Weight: 203.0515232
• Mol File: 405931-46-6.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 192.028°C at 760 mmHg
• Flash Point: 72.438°C
• Appearance: /
• Density: 1.446g/cm³
• Vapor Pressure: 0.695mmHg at 25°C
• Refractive Index: 1.532
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• CAS DataBase Reference: 1-(1-Bromoethyl)-2-Fluorobenzene(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(1-Bromoethyl)-2-Fluorobenzene(405931-46-6)
• EPA Substance Registry System: 1-(1-Bromoethyl)-2-Fluorobenzene(405931-46-6)

Safety Data

• Hazardous Substances Data: 405931-46-6(Hazardous Substances Data)

Usage

General Description

1-(1-Bromoethyl)-2-Fluorobenzene is a chemical compound with the molecular formula C8H8BrF. It is a colorless liquid with a molecular weight of 189.05 g/mol. This chemical is commonly used as a building block in the synthesis of various pharmaceuticals, agrochemicals, and other organic compounds. It is also used as a reagent in organic chemistry reactions, such as nucleophilic aromatic substitution and cross-coupling reactions. Additionally, 1-(1-Bromoethyl)-2-Fluorobenzene is known to be harmful if swallowed, inhaled, or in contact with the skin, and therefore, should be handled with proper safety precautions in a well-ventilated area.

InChI:InChI=1/C8H8BrF/c1-6(9)7-4-2-3-5-8(7)10/h2-6H,1H3

Upstream product

• 445-26-1 1-(2-fluorophenyl)ethanol 
• 445-27-2 2'-Fluoroacetophenone 
• 394-46-7 2-fluorostyrene 

Downstream Products

• 1402851-59-5 (S)-1-(1-cyclopentylethyl)-2-fluorobenzene 
• 1402851-76-6 (R)-1-(1-cyclopentylethyl)-2-fluorobenzene 

Relevant articles and documents

1-ALKYL-PYRAZOLES AND -INDAZOLES AS BUB1 INHIBITORS FOR THE TREATMENT OF HYPERPROLIFERATIVE DISEASES

Compounds of formula (I) and their use as pharmaceuticals.

NOVEL TRPV3 MODULATORS

Disclosed herein are modulators of TRPV3 of formula (I) wherein G1, X1, X2, X3, X4, X5, G2, Z1, Ra, Rb, u, and p are as defined in the specification. Compositions comprising such compounds and methods for treating conditions and disorders using such compounds and compositions are also presented.

Catalytic enantioselective cross-couplings of secondary alkyl electrophiles with secondary alkylmetal nucleophiles: Negishi reactions of racemic benzylic bromides with achiral alkylzinc reagents

We have developed a nickel-catalyzed method for the asymmetric cross-coupling of secondary electrophiles with secondary nucleophiles, specifically, stereoconvergent Negishi reactions of racemic benzylic bromides with achiral cycloalkylzinc reagents. In contrast to most previous studies of enantioselective Negishi cross-couplings, tridentate pybox ligands are ineffective in this process; however, a new, readily available bidentate isoquinoline-oxazoline ligand furnishes excellent ee's and good yields. The use of acyclic alkylzinc reagents as coupling partners led to the discovery of a highly unusual isomerization that generates a significant quantity of a branched cross-coupling product from an unbranched nucleophile.