40601-43-2

Basic information

• Product Name: Phosphonic acid, (2-cyclohexyl-2-oxoethyl)-, diethyl ester
• CAS NO: 40601-43-2
• Molecular Formula: C12H23O4P
• Molecular Weight: 262.286
• Mol File: 40601-43-2.mol
• Article Data: 10

Chemical Properties

• CAS DataBase Reference: Phosphonic acid, (2-cyclohexyl-2-oxoethyl)-, diethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Phosphonic acid, (2-cyclohexyl-2-oxoethyl)-, diethyl ester(40601-43-2)
• EPA Substance Registry System: Phosphonic acid, (2-cyclohexyl-2-oxoethyl)-, diethyl ester(40601-43-2)

Safety Data

• Hazardous Substances Data: 40601-43-2(Hazardous Substances Data)

Upstream product

• 15972-15-3 1-cyclohexyl-butane-1,3-dione 
• 762-04-9 phosphonic acid diethyl ester 
• 78-27-3 1-Ethynylcyclohexan-1-ol 
• 4630-82-4 methyl cyclohexylcarboxylate 
• 10419-77-9 diethyl iodomethanephosphonate 
• 683-08-9 Diethyl methylphosphonate 
• 2719-27-9 cyclohexanylcarbonyl chloride 
• 66130-90-3 diethyl <<(trimethylsilyl)oxy>carbonyl>methanephosphonate 
• 95-54-5 1,2-diamino-benzene 
• 30238-20-1 diethyl cyclohexylethynylphosphonate 
• 3095-95-2 diethylphosphonoacetic acid 

Downstream Products

• 1421338-23-9 C₂₂H₂₃N₃O₃S 

Relevant articles and documents

Silver-Catalyzed Oxidative C(sp3)?P Bond Formation through C?C and P?H Bond Cleavage

The silver-catalyzed oxidative C(sp3)?H/P?H cross-coupling of 1,3-dicarbonyl compounds with H-phosphonates, followed by a chemo- and regioselective C(sp3)?C(CO) bond-cleavage step, provided heavily functionalized β-ketophosphonates. This novel method based on a readily available reaction system exhibits wide scope, high functional-group tolerance, and exclusive selectivity.

Gold(I)-catalyzed hydration of alkynylphosphonates: Efficient access to β-ketophosphonates

A general, efficient, and highly regioselective protocol with the use of a gold(I) complex catalytic system for the transformation of alkynylphosphonates into the corresponding β-ketophosphonates has been successfully developed. This method produces a variety of β-ketophosphonates with the advantages of mild reaction conditions, high functional-group tolerance, and excellent yields. An efficient and mild gold-catalyzed hydration process for the regioselective synthesis of β-ketophosphonates directly from alkynylphosphonates is described. Twenty-two examples with yields of 85-97 % are reported. Different substituents including substituted aryl, alkyl, chloro, ester, sulfonoxyl, and phthalimide groups are tolerated; XPhos = 2-dicyclohexylphosphino-2′,4′,6′-triisopropylbiphenyl, Tf = trifluoromethylsulfonyl. Copyright

Novel cobalt(0)- or magnesium-mediated approaches to β-ketophosphonates

Two novel approaches to β-ketophosphonates, based on cobalt(0)- or magnesium-mediated reactions of α-halophosphonates with esters are described.