40601-45-4

Basic information

• Product Name: Diethyl-(2-oxo-4-phenylbutyl)phosphonate, 98 %
• Synonyms: Diethyl-(2-oxo-4-phenylbutyl)phosphonate, 98 %
• CAS NO: 40601-45-4
• Molecular Formula: C₁₄H₂₁O₄P
• Molecular Weight: 284.29
• Mol File: 40601-45-4.mol
• Article Data: 6

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Diethyl-(2-oxo-4-phenylbutyl)phosphonate, 98 %(CAS DataBase Reference)
• NIST Chemistry Reference: Diethyl-(2-oxo-4-phenylbutyl)phosphonate, 98 %(40601-45-4)
• EPA Substance Registry System: Diethyl-(2-oxo-4-phenylbutyl)phosphonate, 98 %(40601-45-4)

Safety Data

• Hazardous Substances Data: 40601-45-4(Hazardous Substances Data)

Upstream product

• 104-53-0 3-phenyl-propionaldehyde 
• 25411-73-8 diethyl diazomethylphosphonate 
• 352276-27-8 1-iodo-4-phenylbutan-2-one 
• 122-52-1 triethyl phosphite 
• 10419-77-9 diethyl iodomethanephosphonate 
• 103-25-3 3-phenylpropanoic acid methyl ester 
• 645-45-4 hydrocinnamic acid chloride 
• 2550-26-7 4-Phenyl-2-butanone 
• 31984-10-8 1-bromo-4-phenylbutan-2-one 
• 762-04-9 phosphonic acid diethyl ester 
• 768-56-9 4-Phenylbut-1-ene 

Downstream Products

• 2550-26-7 4-Phenyl-2-butanone 
• 82102-19-0 2-amino-4-phenylbutylphosphonic acid 
• 1217357-13-5 2-(hydroxymethyl)-5-phenylpent-1-en-3-one 
• 55076-60-3 (3aR,4R,5R,6aS)-2-oxo-4-((1E)-3-oxo-5-phenylpent-1-en-1-yl)-hexahydro-2H-cyclopenta[b]furan-5-yl benzoate 
• 55444-68-3 (3aR,4R,5R,6aS)-4-[(1E,3S)-3-hydroxy-5-phenylpent-1-en-1-yl]-2-oxo-hexahydro-2H-cyclopenta[b]furan-5-yl benzoate 
• 41639-74-1 (3aR,4R,5R,6aS)-hexahydro-5-hydroxy-4-[(1E,3S)-5-phenyl-3-hydroxy-(1E)-pentenyl]-2H-cyclopentane [β] furan-2-one 
• 856240-62-5 (3aR,4R,5R,6aS)-hexahydro-4-[(1E,3S)-3-hydroxy-5-phenyl-1-penten-1-yl]-2H-cyclopenta[b]furan-2,5-diol 
• 155206-00-1 bimatoprost 

Relevant articles and documents

Manganese-catalyzed oxophosphorylation reaction of carbon–carbon double bonds using molecular oxygen in air

A novel aerobic manganese-catalyzed oxophosphorylation reaction of carbon–carbon double bonds of styrene derivatives and vinyl ethers using diethyl H-phosphonates was developed. This direct transformation of alkenes to β-ketophosphonate readily proceeded at room temperature via the direct incorporation of molecular oxygen present in air (open flask).

Novel method for preparing Prostaglandin derivatives

Provided is a novel method for preparing prostaglandin derivatives. The method is suitable for mass production by effectively manufacturing prostaglandin derivatives with high yield. The method comprises the following steps: (S-1) adding a first reducing agent to a prostaglandin intermediate compound represented by chemical formula II and manufacturing a compound represented by chemical formula III; (S-2) manufacturing a compound represented by chemical formula IV from the compound represented by chemical formula III in the presence of a base; (S-3) adding a second reducing agent to the compound represented by chemical formula IV and manufacturing a compound represented by chemical formula V; and (S-4) performing Wittig reaction of the compound represented by chemical formula V and a compound represented by chemical formula VI, and manufacturing a compound represented by chemical formula I.COPYRIGHT KIPO 2017

Preparation of 1-aminoalkylphosphonic acids and 2-aminoalkylphosphonic acids by reductive amination of oxoalkylphosphonates

By reacting dialkyl 1-oxo- or 2-oxoalkylphosphonates with benzhydrylamine followed by reduction with triacetoxyborohydride and acid hydrolysis gave corresponding aminoalkylphosphonic acids with satisfactory yields. The use of benzylamine, α-methylbenzylamine and tritylamine was unsuccessful in the case of dialkyl 1-oxoalkylphosphonates whereas conversion of 2-oxoalkylphosphonates was also achieved although with lower yields.