40608-76-2

Basic information

• Product Name: 2-BENZYL-5-METHOXY-1H-BENZO[D]IMIDAZOLE
• Synonyms: 2-BENZYL-5-METHOXY-1H-BENZO[D]IMIDAZOLE
• CAS NO: 40608-76-2
• Molecular Formula: C₁₅H₁₄N₂O
• Molecular Weight: 238.29
• Mol File: 40608-76-2.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 2-BENZYL-5-METHOXY-1H-BENZO[D]IMIDAZOLE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-BENZYL-5-METHOXY-1H-BENZO[D]IMIDAZOLE(40608-76-2)
• EPA Substance Registry System: 2-BENZYL-5-METHOXY-1H-BENZO[D]IMIDAZOLE(40608-76-2)

Safety Data

• Hazardous Substances Data: 40608-76-2(Hazardous Substances Data)

Usage

General Description

2-Benzyl-5-methoxy-1H-benzo[d]imidazole is a chemical compound with the molecular formula C15H14N2O. It is a heterocyclic compound that contains a benzimidazole ring system with a benzyl and a methoxy substituent. 2-BENZYL-5-METHOXY-1H-BENZO[D]IMIDAZOLE has potential applications in the pharmaceutical industry as it possesses various biological activities, such as anti-cancer and anti-inflammatory properties. It is also used as a building block in organic synthesis and medicinal chemistry. Additionally, research has shown that this compound exhibits cytotoxic effects against certain cancer cell lines, making it a potential candidate for the development of new anti-cancer drugs.

Upstream product

• 103-82-2 phenylacetic acid 
• 102-51-2 4-methoxy-1,2-phenylenediamine 
• 96-96-8 4-methoxy-2-nitroaniline 
• 2019-10-5 N-(4-methoxy-2-nitrophenyl) phenylacetamide 
• 1272902-62-1 C₁₅H₁₆N₂O₂ 
• 16133-49-6 5-methoxy-2-nitroaniline 
• 14661-56-4 5-Methoxy-2-nitro-α-phenylacetanilid 
• 122-78-1 phenylacetaldehyde 
• 103-80-0 phenylacetyl chloride 

Downstream Products

• 1370000-18-2 C₁₉H₂₁N₃O 
• 131336-23-7 2-benzyl-5⁽⁶⁾-hydroxybenzimidazole 

Relevant articles and documents

Exploration of 2-benzylbenzimidazole scaffold as novel inhibitor of NF-κB

For finding the novel inhibitor of nuclear factor κB activity, a series of benzimidazole derivatives were rationally designed, synthesized and systematically studied for their in vitro activities against LPS induced NF-κB inhibition in RAW 264.7 cells using the SEAP assay based on the flexible chalcone JSH ((E)-1-(2-hydroxy-6-(isopentyloxy)phenyl)-3-(4-hydroxy phenyl)prop-2-en-1-one) which was previously reported. Although most of the benzimidazole derivatives showed strong inhibitory activity in low micromolar potency, 2-(4-methoxybenzyl)-1H-benzo[d]imidazole (3m; IC50 = 1.7 μM) and 2-(2-methoxybenzyl)-1H-benzo[d]imidazole (3n; IC50 = 2.4 μM) showed the best inhibition. The structure activity relationship revealed that 2-benzylbenzimidazole scaffold with hydrogen bonding acceptor on phenyl ring appears as a pharmacophore.

Method for treating neoplasia by exposure to substituted 2-aryl-benzimidazole derivatives

A method for inhibiting neoplasia, particularly cancerous and precancerous lesions, by exposing the affected cells to substituted 2-aryl-benzimidazoles.