40611-52-7Relevant articles and documents
Design, syntheses and evaluation of benzoylthioureas as urease inhibitors of agricultural interest
Brito, Tiago O.,Souza, Aline X.,Mota, Yane C. C.,Morais, Vinicius S. S.,De Souza, Leandro T.,De Fátima, ?ngelo,Macedo, Fernando,Modolo, Luzia V.
, p. 44507 - 44515 (2015)
Urea is one of the most used nitrogen fertilizers worldwide. However, occurrence of urea hydrolysis to ammonia and carbon dioxide on soil surface, catalyzed by soil ureases, considerably reduces nitrogen availability to crops. In this study, we describe the design, synthesis and screening of sixty five benzoylthioureas (BTUs) for their ability to inhibit purified jack bean and soil ureases. BTUs were readily obtained in one pot, two steps synthesis with no need of cumbersome procedures for product purification. In vitro assays revealed BTUs 11, 12, 14, 19-22 and 37 as the most active jack bean urease inhibitors. Such BTUs were found to be able to bind to both catalytic and allosteric sites of urease, acting therefore as mixed-type inhibitors. Out of 28 compounds that effectively inhibited soil ureases activity, BTUs 3, 6, 10, 12, 16, 19 and 22 were determined to be more potent than the reference inhibitor N-(butyl) thiophosphoric triamide (NBPT; 40%). The other 22 BTUs were as potent as NBPT on soil ureases. The temperature-tolerance of BTUs, along with their ability to inhibit soil ureases, makes of this class of compounds potential additive for urea-based fertilizers.
TRANSFORMATION PHOTOCHIMIQUE DE DERIVES DE LA BENZOYL-AMINO-2 Δ2-THIAZOLINE PAR RUPTURE D'UNE LIAISON C-S. ETUDE SPECTROSCOPIQUE DES DERIVES DE LA N-ETHYL N'-BENZOYL THIOUREE OBTENUS.
Jardon, P.,Azarnouche, B.,Corval, A.,Gautron, R.
, p. 603 - 608 (2007/10/02)
The phototransformation of the following 2-amino-Δ2-thiazoline derivatives have been studied: 4-chlorobenzoyl, 4-methyl benzoyl, benzoyl, 2-chloro benzoyl, 2-methyl benzoyl.Irradiation of a deaerated cyclohexane solution of these compounds gave corresponding derivatives of N-ethyl N'-benzoyl thiurea, the formation of which may be rationalized by homolytic cleavage of the C-S bond followed by hydrogen abstraction from the solvent.According to photophysical data previously obtained, a kinetic model is proposed.The relative values of the formation rate constant of a biradical intermediate are calculated and a relation between this rate constant and the first triplet state energy is established.UV, IR, 1H NMR and 13C NMR spectra of the photoproducts have been recorded and the main spectral data are presented.
