406212-57-5

Basic information

• Product Name: tert-butyl 3-{2-amino-6-[2,6-bis(benzyloxy)phenyl]-3-cyano-4-pyridinyl}-1-piperidinecarboxylate
• Synonyms: tert-butyl 3-{2-amino-6-[2,6-bis(benzyloxy)phenyl]-3-cyano-4-pyridinyl}-1-piperidinecarboxylate
• CAS NO: 406212-57-5
• Molecular Weight: 590.722
• Mol File: 406212-57-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: tert-butyl 3-{2-amino-6-[2,6-bis(benzyloxy)phenyl]-3-cyano-4-pyridinyl}-1-piperidinecarboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: tert-butyl 3-{2-amino-6-[2,6-bis(benzyloxy)phenyl]-3-cyano-4-pyridinyl}-1-piperidinecarboxylate(406212-57-5)
• EPA Substance Registry System: tert-butyl 3-{2-amino-6-[2,6-bis(benzyloxy)phenyl]-3-cyano-4-pyridinyl}-1-piperidinecarboxylate(406212-57-5)

Safety Data

• Hazardous Substances Data: 406212-57-5(Hazardous Substances Data)

Upstream product

• 3886-19-9 1-[2',6'-bis(phenylmethoxy)phenyl]ethanone 
• 109-77-3 malononitrile 
• 118156-93-7 3-formylpiperidine-1-carboxylic acid tert-butyl ester 

Downstream Products

• 406212-59-7 tert-butyl 3-{2-amino-6-[2-(benzyloxy)-6-hydroxyphenyl]-3-cyano-4-pyridinyl}-1-piperidinecarboxylate 
• 406212-58-6 tert-butyl 3-[2-amino-3-cyano-6-(2,6-dihydroxy-phenyl)-4-pyridinyl]-1-piperidinecarboxylate 

Relevant articles and documents

Synthesis and structure-activity relationships of novel IKK-β inhibitors. Part 3: Orally active anti-inflammatory agents

A series of 2-amino-3-cyano-4-alkyl-6-(2-hydroxyphenyl)pyridine derivatives was synthesized and evaluated as IκB kinase β (IKK-β) inhibitors. Modification of a novel IKK-β inhibitor 1 (IKK-β IC 50=1500nM, Cell IC50=8000nM) at the 4-p