406219-72-5

Basic information

• Product Name: 2-[4-(2-fluorophenyl)phenyl]-3-[(2-methoxycarbonyl)ethyl]-4-methoxymethyl-6-fluoroquinoline
• Synonyms: 2-[4-(2-fluorophenyl)phenyl]-3-[(2-methoxycarbonyl)ethyl]-4-methoxymethyl-6-fluoroquinoline
• CAS NO: 406219-72-5
• Molecular Weight: 447.481
• Mol File: 406219-72-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-[4-(2-fluorophenyl)phenyl]-3-[(2-methoxycarbonyl)ethyl]-4-methoxymethyl-6-fluoroquinoline(CAS DataBase Reference)
• NIST Chemistry Reference: 2-[4-(2-fluorophenyl)phenyl]-3-[(2-methoxycarbonyl)ethyl]-4-methoxymethyl-6-fluoroquinoline(406219-72-5)
• EPA Substance Registry System: 2-[4-(2-fluorophenyl)phenyl]-3-[(2-methoxycarbonyl)ethyl]-4-methoxymethyl-6-fluoroquinoline(406219-72-5)

Safety Data

• Hazardous Substances Data: 406219-72-5(Hazardous Substances Data)

Upstream product

• 406219-68-9 2-[4-(2-fluorophenyl)phenyl]-3-[(2-methoxycarbonyl)ethyl]-6-fluoroquinoline-4-carboxylic acid 
• 213541-12-9 2-[4-(2-fluorophenyl)phenyl]-3-(2-carboxyethyl)-6-fluoroquinoline-4-carboxylic acid 
• 406219-65-6 5-(2'-fluoro-biphenyl-4-yl)-5-oxo-pentanoic acid methyl ester 
• 321-60-8 2-fluorobiphenyl 
• 1501-26-4 methyl 4-(chlorocarbonyl)butyrate 
• 213541-01-6 2-[4-(2-fluorophenyl)phenyl]-3-[(2-methoxycarbonyl)ethyl]-4-hydroxymethyl-6-fluoroquinoline 
• 74-88-4 methyl iodide 

Downstream Products

• 406219-74-7 2-[4-(2-fluorophenyl)phenyl]-3-(2-carboxyethyl)-4-methoxymethyl-6-fluoroquinoline 

Relevant articles and documents

Synthetic study on novel immunosuppressant KF20444.

The two new synthetic routes to 6,7-dihydro-10-fluoro-3-(2-fluorophenyl)-5H- benzo[6,7]cyclohepta[1,2-b]-quinoline-8-carboxylic acid (1), a novel immunosuppressant KF20444, are described. The seven-membered ring construction from 2-[4-(2-fluorophenyl)phenyl]-3-(2-carboxyethyl)-4-chloromethyl-6-fluoroquinoline (17c) was achieved by intramolecular Friedel-Crafts reaction under acidic conditions as the key step. Subsequently, the oxidation of 4-chloromethyl group followed by reduction of carbonyl group on the seven-membered ring afforded 1. This route provides a new method for the synthesis of 1.