40630-75-9

Basic information

• Product Name: 2,2-Dimethyl-4-dodecanoyloxymethyl-1,3-dioxolane
• Synonyms: 2,2-Dimethyl-4-dodecanoyloxymethyl-1,3-dioxolane;Dodecanoic acid 2,2-dimethyl-1,3-dioxolan-4-ylmethyl ester;Lauric acid 2,2-dimethyl-1,3-dioxolan-4-ylmethyl ester
• CAS NO: 40630-75-9
• Molecular Formula: C₁₈H₃₄O₄
• Molecular Weight: 0
• Mol File: 40630-75-9.mol
• Article Data: 7

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2,2-Dimethyl-4-dodecanoyloxymethyl-1,3-dioxolane(CAS DataBase Reference)
• NIST Chemistry Reference: 2,2-Dimethyl-4-dodecanoyloxymethyl-1,3-dioxolane(40630-75-9)
• EPA Substance Registry System: 2,2-Dimethyl-4-dodecanoyloxymethyl-1,3-dioxolane(40630-75-9)

Safety Data

• Hazardous Substances Data: 40630-75-9(Hazardous Substances Data)

Upstream product

• 143-07-7 lauric acid 
• 100-79-8 (R,S)-2,2-dimethyl-1,3-dioxolane-4-methanol 
• 112-16-3 n-dodecanoyl chloride 
• 67-64-1 acetone 

Downstream Products

• 40738-26-9 rac-1-monolauroylglycerol 

Relevant articles and documents

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Amorphous SiO2-SO3H [1] with a small surface area and 1.32-mmol H+/g was used for the one-step preparation of solketal from glycerol and acetone; a 20%-w/w catalyst mixture (10% [1] and 10% (Bu4N)(BF4) was found to be very efficient for the synthesis of disolketal ether and of oxygenated biofuels fatty acids solketal esters (FASEs), by direct esterification of the caprylic, lauric, stearic, oleic and linoleic acids with solketal in a 4:1 acid:solketal ratio in refluxing toluene. Solketal acetate was also produced in quantitative yields.

Synthesis of the fatty esters of solketal and glycerol-formal: Biobased specialty chemicals

The caprylic, lauric, palmitic and stearic esters of solketal and glycerol formal were synthesized with high selectivity and in good yields by a solvent-free acid catalyzed procedure. No acetal hydrolysis was observed, notwithstanding the acidic reaction conditions.

Preparation of diacid 1,3-diacylglycerols

A complete methodology (including synthesis, purification and analysis) for the preparation of 1,3-DAG is described. For a successful synthesis project, the strengths and weaknesses of each particular process should be taken into account and measures taken to offset or balance potential weaknesses. To this end, we describe some of the challenges associated with: chemically and enzymatically catalyzed acylglycerol syntheses; recrystallization and flash chromatography for purification of partial acylglycerols; and thin-layer chromatography (TLC) separation of DAG. For this work, 1-MAG intermediates and subsequent diacid 1,3-DAG were prepared using non-enzymatic methods, whereas, monoacid 1,3-DAG were prepared by enzymatic methods. It was not always possible to obtain pure samples of target compounds-in recrystallizations this is due to solid solution formation and co-crystallization and in chromatographic separations it is due to co-elution of components with similar Rf. Furthermore, TLC Rf of DAG is determined by two main factors: acyl chain length and positional isomerism. Interestingly, while the role of positional isomerism is well-known, the role of acyl chain length in these separations has only recently come to light.