40632-21-1 Usage
Description
URIDINE-5,6-D2 is a labeled nucleoside, which is a derivative of uridine, one of the four basic components of ribonucleic acid (RNA). It is a white solid and is widely distributed in nature. The presence of deuterium (D2) in the molecule allows for its use in various applications, particularly in research and development.
Uses
Used in Research and Development:
URIDINE-5,6-D2 is used as a labeled compound for studying the structure, function, and interactions of RNA molecules in biological systems. The deuterium labeling provides a unique signature for the compound, enabling researchers to track its behavior and interactions within cells and organisms.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, URIDINE-5,6-D2 is used as a building block for the synthesis of various RNA-based therapeutics and diagnostic tools. The deuterium labeling can improve the stability and pharmacokinetic properties of these molecules, making them more suitable for clinical applications.
Used in Diagnostic Applications:
URIDINE-5,6-D2 can be employed as a labeled reference material for the development of diagnostic assays and tests that target RNA molecules. The deuterium labeling allows for accurate quantification and detection of specific RNA species, which can be useful in disease diagnosis and monitoring.
Used in Biochemical Studies:
URIDINE-5,6-D2 is used as a labeled substrate for studying enzymatic reactions involving RNA metabolism, such as RNA synthesis, modification, and degradation. The deuterium labeling can help researchers investigate the mechanisms and kinetics of these reactions, providing valuable insights into RNA biology and its regulation.
Used in Drug Delivery Systems:
Similar to gallotannin, URIDINE-5,6-D2 can be incorporated into novel drug delivery systems to enhance the delivery, bioavailability, and therapeutic outcomes of RNA-based drugs. The deuterium labeling can improve the stability and targeting of these delivery systems, potentially leading to more effective treatments for various diseases and conditions.
Check Digit Verification of cas no
The CAS Registry Mumber 40632-21-1 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 4,0,6,3 and 2 respectively; the second part has 2 digits, 2 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 40632-21:
(7*4)+(6*0)+(5*6)+(4*3)+(3*2)+(2*2)+(1*1)=81
81 % 10 = 1
So 40632-21-1 is a valid CAS Registry Number.
InChI:InChI=1/C9H12N2O6/c12-3-4-6(14)7(15)8(17-4)11-2-1-5(13)10-9(11)16/h1-2,4,6-8,12,14-15H,3H2,(H,10,13,16)/t4-,6+,7?,8-/m1/s1/i1D,2D
40632-21-1Relevant articles and documents
Palladium-catalyzed base-selective H-D exchange reaction of nucleosides in deuterium oxide
Sajiki, Hironao,Esaki, Hiroyoshi,Aoki, Fumiyo,Maegawa, Tomohiro,Hirota, Kosaku
, p. 1385 - 1388 (2007/10/03)
We have developed an efficient and extensive deuterium incorporation method using a heterogeneous Pd/C-D2O-H2 system into the base moiety of nucleosides. The results presented here provide a deuterium gas-free, totally catalytic, and post-synthetic deuterium labeling method in D 2O media. Georg Thieme Verlag Stuttgart.
METHOD FOR DEUTERATION OR TRITIATION OF HETEROCYCLIC RING
-
Page/Page column 17, (2008/06/13)
The present invention relates to a method for deuteration of a heterocyclic ring, which comprises subjecting a compound having a heterocyclic ring to sealed refluxing state in a deuterated solvent in the presence of an activated catalyst selected form a palladium catalyst, a platinum catalyst, a rhodium catalyst, a ruthenium catalyst, a nickel catalyst and a cobalt catalyst. In accordance with a method of the present invention, a hydrogen atom belonging to a heterocyclic ring of a compound having a heterocyclic ring can be very efficiently deuterated because temperature of deuteration reaction can be maintained at higher than boiling point of the solvent. Further, a method for deuteration of the present invention can be applied widely to deuteration of various compounds having a heterocyclic ring which are liable to decomposition under supercritical conditions or acidic conditions, leading to industrial and efficient deuteration of a compound having a heterocyclic ring.
