4064-57-7

Basic information

• Product Name: (11beta)-9-fluoro-11-hydroxypregna-4,16-diene-3,20-dione
• Synonyms: 9-Fluoro-11beta-hydroxypregna-4,16-diene-3,20-dione
• CAS NO: 4064-57-7
• Molecular Formula: C₂₁H₂₇FO₃
• Molecular Weight: 346.4357
• Mol File: 4064-57-7.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 501°C at 760 mmHg
• Flash Point: 256.8°C
• Density: 1.21g/cm³
• Vapor Pressure: 3.87E-12mmHg at 25°C
• Refractive Index: 1.563
• CAS DataBase Reference: (11beta)-9-fluoro-11-hydroxypregna-4,16-diene-3,20-dione(CAS DataBase Reference)
• NIST Chemistry Reference: (11beta)-9-fluoro-11-hydroxypregna-4,16-diene-3,20-dione(4064-57-7)
• EPA Substance Registry System: (11beta)-9-fluoro-11-hydroxypregna-4,16-diene-3,20-dione(4064-57-7)

Safety Data

• Hazardous Substances Data: 4064-57-7(Hazardous Substances Data)

Usage

Description

(11beta)-9-fluoro-11-hydroxypregna-4,16-diene-3,20-dione is a synthetic corticosteroid derived from the natural hormone cortisol. It possesses anti-inflammatory and immunosuppressive properties, making it a valuable compound for treating various inflammatory and autoimmune conditions.
Used in Pharmaceutical Industry:
(11beta)-9-fluoro-11-hydroxypregna-4,16-diene-3,20-dione is used as an anti-inflammatory and immunosuppressive agent for the treatment of various inflammatory and autoimmune conditions, such as asthma, rheumatoid arthritis, and dermatitis. It functions by inhibiting the production of inflammatory substances in the body and suppressing the immune response, providing relief from symptoms and managing the progression of these conditions.
However, it is important to note that the use of (11beta)-9-fluoro-11-hydroxypregna-4,16-diene-3,20-dione also carries the risk of various side effects, including increased susceptibility to infections, osteoporosis, and adrenal suppression. Therefore, its use should be carefully monitored and managed by healthcare professionals to ensure the safety and effectiveness of the treatment.

Upstream product

• 110663-31-5 9,11β;16α,17-diepoxy-9β-pregn-4-ene-3,20-dione 
• 110053-24-2 9-bromo-16α,17-epoxy-11β-hydroxy-pregn-4-ene-3,20-dione 
• 3827-33-6 16α,17-epoxy-9-fluoro-11β-hydroxy-pregn-4-ene-3,20-dione 

Downstream Products

• 2135-14-0 9-fluoro-11β-hydroxy-16α,17-isopropylidenedioxy-pregna-1,4-diene-3,20-dione 
• 595-52-8 9-fluoro-11β,16α,17-trihydroxy-pregna-1,4-diene-3,20-dione 

Relevant articles and documents

On a pregnane - 16 - ene - 3, 20 - dione steroid derivatives preparation method

The invention relates to a preparation method for a pregna-16-ene-3, 20-dione steroid derivative (II). The method is characterized by: reacting 17alpha-ethynyl-17beta-hydroxysteroid derivative I with a reagent A or an organic solvent containing the reagent A to obtaining the derivative (II). The reaction temperature ranges from 25DEG C to a solvent reflux temperature, and the reagent A is a solution formed by dissolving 5%-15% of phosphorus pentoxide in methanesulfonic acid.