406482-19-7 Usage
Description
2-FLUORO-5-METHOXYPHENYLBORONIC ACID is an organic compound that features a boronic acid functional group with a fluorine atom at the 2nd position and a methoxy group at the 5th position on a phenyl ring. 2-FLUORO-5-METHOXYPHENYLBORONIC ACID is known for its reactivity and stability, making it a versatile building block in organic synthesis and material science.
Uses
Used in Chemical Synthesis:
2-FLUORO-5-METHOXYPHENYLBORONIC ACID is used as a synthetic building block for the creation of various organic compounds due to its unique structure and reactivity.
Used in Pharmaceutical Industry:
2-FLUORO-5-METHOXYPHENYLBORONIC ACID is used as a key intermediate in the synthesis of pharmaceutical compounds, particularly those with potential applications in drug discovery and development.
Used in Suzuki Reaction:
In the field of organic chemistry, 2-FLUORO-5-METHOXYPHENYLBORONIC ACID is used as a reactant in Suzuki reactions, which are cross-coupling reactions that facilitate the formation of carbon-carbon bonds, leading to the synthesis of complex organic molecules.
Used in Friedel-Crafts Alkylation of Hydronaphthalenes:
2-FLUORO-5-METHOXYPHENYLBORONIC ACID is employed as a reactant in the Friedel-Crafts alkylation of hydronaphthalenes, a process that involves the electrophilic substitution of an alkyl group onto an aromatic ring, resulting in the formation of new organic compounds.
Used in Synthesis of 9,10-Diarylanthracenes:
2-FLUORO-5-METHOXYPHENYLBORONIC ACID is used as a starting material in the synthesis of 9,10-diarylanthracenes, which are organic compounds with potential applications as molecular switches in material science.
Used in Cross-Coupling with Carbazolyl or Aryl Halides:
In the field of material science, 2-FLUORO-5-METHOXYPHENYLBORONIC ACID is used in cross-coupling reactions with carbazolyl or aryl halides, leading to the formation of novel organic compounds with potential applications in optoelectronics and other advanced technologies.
Check Digit Verification of cas no
The CAS Registry Mumber 406482-19-7 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 4,0,6,4,8 and 2 respectively; the second part has 2 digits, 1 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 406482-19:
(8*4)+(7*0)+(6*6)+(5*4)+(4*8)+(3*2)+(2*1)+(1*9)=137
137 % 10 = 7
So 406482-19-7 is a valid CAS Registry Number.
InChI:InChI=1/C7H8BFO3/c1-12-5-2-3-7(9)6(4-5)8(10)11/h2-4,10-11H,1H3
406482-19-7Relevant articles and documents
Fast and Tight Boronate Formation for Click Bioorthogonal Conjugation
Akgun, Burcin,Hall, Dennis G.
supporting information, p. 3909 - 3913 (2016/03/19)
A new click bioorthogonal reaction system was devised to enable the fast ligation (kON≈340 m-1 s-1) of conjugatable derivatives of a rigid cyclic diol (nopoldiol) and a carefully optimized boronic acid partner, 2-methyl-5-carboxymethylphenylboronic acid. Using NMR and fluorescence spectroscopy studies, the corresponding boronates were found to form reversibly within minutes at low micromolar concentration in water, providing submicromolar equilibrium constant (Keq≈105-106 m-1). Efficient protein conjugation under physiological conditions was demonstrated with model proteins thioredoxin and albumin, and characterized by mass spectrometry and gel electrophoresis.
