40649-25-0

Basic information

• Product Name: N-cyclopentylcyclohexanamine
• Synonyms: N-cyclopentylcyclohexanamine;UKRORGSYN-BB BBV-120138;N-cyclopentylcyclohexanamine(SALTDATA: HBr)
• CAS NO: 40649-25-0
• Molecular Formula: C₁₁H₂₁N
• Molecular Weight: 167.29
• Mol File: 40649-25-0.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 238.8°C at 760 mmHg
• Flash Point: 92.1°C
• Appearance: /
• Density: 0.91g/cm³
• Vapor Pressure: 0.0415mmHg at 25°C
• Refractive Index: 1.489
• CAS DataBase Reference: N-cyclopentylcyclohexanamine(CAS DataBase Reference)
• NIST Chemistry Reference: N-cyclopentylcyclohexanamine(40649-25-0)
• EPA Substance Registry System: N-cyclopentylcyclohexanamine(40649-25-0)

Safety Data

• Hazardous Substances Data: 40649-25-0(Hazardous Substances Data)

Usage

InChI:InChI=1/C11H21N/c1-2-6-10(7-3-1)12-11-8-4-5-9-11/h10-12H,1-9H2

Upstream product

• 42908-34-9 N-cyclohexyl-N-cyclopentylidenamine 
• 19573-22-9 cyclohexyl azide 
• 142-29-0 cyclopentene 
• 108-91-8 cyclohexylamine 
• 120-92-3 cyclopentanone 
• 108-94-1 cyclohexanone 
• 1003-03-8 Cyclopentamine 

Downstream Products

• 108798-97-6 cyclohexyl-cyclopentyl-dimethyl-ammonium; iodide 
• 207851-43-2 N-cyclohexyl-N-cyclopentylformamide 
• 149556-37-6 4-bromo-3-methyl benzoic acid N-cyclopentyl-N-cyclohexyl amide 
• 149556-36-5 p-bromobenzoic acid N-cyclopentyl-N-cyclohexyl amide 

Relevant articles and documents

High-Throughput Screening of Reductive Amination Reactions Using Desorption Electrospray Ionization Mass Spectrometry

This study describes the latest generation of a high-throughput screening system that is capable of screening thousands of organic reactions in a single day. This system combines a liquid handling robot with desorption electrospray ionization (DESI) mass spectrometry (MS) for a rapid reaction mixture preparation, accelerated synthesis, and automated MS analysis. A total of 3840 unique reductive amination reactions were screened to demonstrate the throughputs that are capable with the system. Products, byproducts, and intermediates were all monitored in full-scan mass spectra, generating a complete view of the reaction progress. Tandem mass spectrometry experiments were conducted to verify the identity of the products formed. The amine and electrophile reactivity trends represented in the data match what is expected from theory, indicating that the system accurately models the reaction performance. The DESI results correlated well with those generated using more traditional mass spectrometry techniques like liquid chromatography-mass spectrometry, validating the data generated by the system.

Reductive amination agents: comparison of Na(CN)BH3 and Si-CBH

Reductive amination is a chemical reaction commonly employed by organic chemists in academics and the pharmaceutical industry. In this reaction a carbonyl group is converted to an amine via an imine intermediate, the formation of which is rate limiting. A major reagent necessary for the completion of this reaction is a hydride source, commonly sodium cyanoborohydride (Na(CN)BH3). The objective of this research was to compare the efficacy of Na(CN)BH3 with silica-bound cyanoborohydride (Si-CBH) as hydride sources in reductive amination reactions. Work has shown that reactions employing Si-CBH as a hydride source showed significant improvement, exhibiting an average percent conversion 25% greater than reactions using Na(CN)BH3.