406923-91-9

Basic information

• Product Name: 7-FLUORO-1,2,3,4-TETRAHYDRO-ISOQUINOLINE
• Synonyms: Isoquinoline, 7-fluoro-1,2,3,4-tetrahydro- (9CI);Isoquinoline, 7-fluoro-1,2,3,4-tetrahydro-
• CAS NO: 406923-91-9
• Molecular Formula: C₉H₁₀FN
• Molecular Weight: 151.18
• EINECS: 604-604-1
• Product Categories: HALIDE
• Mol File: 406923-91-9.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 227.6 °C at 760 mmHg
• Flash Point: 91.4 °C
• Appearance: /
• Density: 1.107 g/cm³
• Storage Temp.: 2-8°C(protect from light)
• PKA: 9.29±0.20(Predicted)
• CAS DataBase Reference: 7-FLUORO-1,2,3,4-TETRAHYDRO-ISOQUINOLINE(CAS DataBase Reference)
• NIST Chemistry Reference: 7-FLUORO-1,2,3,4-TETRAHYDRO-ISOQUINOLINE(406923-91-9)
• EPA Substance Registry System: 7-FLUORO-1,2,3,4-TETRAHYDRO-ISOQUINOLINE(406923-91-9)

Safety Data

• Hazardous Substances Data: 406923-91-9(Hazardous Substances Data)

Usage

General Description

7-Fluoro-1,2,3,4-tetrahydro-isoquinoline is an organic compound with the chemical formula C9H10FN. It is a fluorinated derivative of the tetrahydroisoquinoline series and is commonly used as a building block in the synthesis of pharmaceuticals, agrochemicals, and other fine chemicals. 7-FLUORO-1,2,3,4-TETRAHYDRO-ISOQUINOLINE is known for its potential biological activities and has been studied for its pharmacological properties, including its potential as an analgesic and antipsychotic agent. Additionally, 7-fluoro-1,2,3,4-tetrahydro-isoquinoline has been investigated for its potential use as a precursor in the synthesis of various heterocyclic compounds and has shown promise in drug discovery and development.

Upstream product

• 1583-88-6 4-fluoro-2-phenethylamine 
• 912846-63-0 2,2,2-trifluoro-N-[2-(4-fluorophenyl)ethyl]acetamide 
• 912846-64-1 2,2,2-trifluoro-1-(7-fluoro-1,2,3,4-tetrahydroisoquinolin-2-yl)ethan-1-one 
• 885273-83-6 7-fluoro-3,4-dihydro-2H-isoquinolin-1-one 

Downstream Products

• 1028330-60-0 C₂₉H₃₃FN₂O 
• 1236265-31-8 N-ethyl-4-((4-(7-fluoro-3,4-dihydroisoquinolin-2(1H)-yl)-1,3,5-triazin-2-ylamino)methyl)-N-m-tolylbenzamide 

Relevant articles and documents

Photocatalytic deaminative benzylation and alkylation of tetrahydroisoquinolines with N-alkylpyrydinium salts

A ruthenium-catalyzed photoredox coupling of substituted N-aryltetrahydroisoquinolines (THIQs) and different bench-stable pyridinium salts was successfully developed to give fast access to 1-benzyl-THIQs. Furthermore, secondary alkyl and allyl groups were also successfully introduced via the same method. Additionally, the typically applied N-phenyl group in the THIQ substrate could be replaced by the cleavable p-methoxyphenyl (PMP) group and successful N-deprotection was demonstrated.

Catalyst-free cyclization of anthranils and cyclic amines: One-step synthesis of rutaecarpine

An efficient synthesis of a variety of quinazolinone derivatives via a direct cyclization reaction between commercially available anthranils and cyclic amines is described. The developed transformation proceeds with the merits of high step- and atom-efficiency, a broad substrate scope, and good to excellent yields, without additional catalysts, and offers a practical way for the preparation of rutaecarpine and its derivatives with structural diversity.

TRIAZOLOPHTHALAZINE COMPOUNDS, USE AS ANTI-HUMAN IMMUNODEFICIENCY VIRUS INHIBITORS OF HIV VIF-DEPENDENT DEGRADATION OF APOBEC3

The present disclosure is concerned with triazolophthalazine compounds that are capable of inhibiting infection by the Human Immunodeficiency Virus (HIV) by inhibiting HIV Vif-dependent degradation of the APOBEC3 innate immune system. The present disclosu