406949-67-5

Basic information

• Product Name: 1-Chloro-2-phenyl-1-((R)-toluene-4-sulfinyl)-propan-2-ol
• Synonyms: 1-Chloro-2-phenyl-1-((R)-toluene-4-sulfinyl)-propan-2-ol
• CAS NO: 406949-67-5
• Molecular Weight: 308.829
• Mol File: 406949-67-5.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 1-Chloro-2-phenyl-1-((R)-toluene-4-sulfinyl)-propan-2-ol(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Chloro-2-phenyl-1-((R)-toluene-4-sulfinyl)-propan-2-ol(406949-67-5)
• EPA Substance Registry System: 1-Chloro-2-phenyl-1-((R)-toluene-4-sulfinyl)-propan-2-ol(406949-67-5)

Safety Data

• Hazardous Substances Data: 406949-67-5(Hazardous Substances Data)

Upstream product

• 31350-91-1 (R)-chloromethyl p-tolyl sulfoxide 
• 98-86-2 acetophenone 

Downstream Products

• 406949-70-0 (R_S)-(Z)-1-chloro-2-phenyl-1-(p-tolylsulfinyl)-1-propene 
• 406949-69-7 (R_S)-(E)-1-chloro-2-phenyl-1-(p-tolylsulfinyl)-1-propene 
• 406949-71-1 (S)-(-)-2-amino-1-cyano-5-methyl-5-phenyl-1,3-cyclopentadiene 
• 406949-76-6 (R)-(+)-2-amino-1-cyano-5-methyl-5-phenyl-1,3-cyclopentadiene 
• 406949-68-6 Acetic acid 2-chloro-1-methyl-1-phenyl-2-((R)-toluene-4-sulfinyl)-ethyl ester 

Relevant articles and documents

Asymmetric synthesis of 4,4-disubstituted 2-cyclopentenones from optically active 1-chlorovinyl p-tolyl sulfoxides and cyanomethyllithium with formation of a quaternary chiral center

Treatment of optically active 1-chlorovinyl p-tolyl sulfoxides having two different substituents at the 2-position, which were synthesized from unsymmetrical ketones and (R)-(-)-chloromethyl p-tolyl sulfoxide in three steps, with cyanomethyllithium gave optically active 2-amino-1-cyano-5,5-disubstituted-1,3-cyclopentadienes with very high asymmetric induction from the sulfoxide chiral center. The products were converted to the enantiomerically pure 4,4-disubstituted 2-cyclopentenones by heating with phosphoric acid in acetic acid.