4072-14-4

Basic information

• Product Name: Methanone, (2-hydroxy-4,5-dimethylphenyl)phenyl-
• CAS NO: 4072-14-4
• Molecular Formula: C15H14O2
• Molecular Weight: 226.275
• Mol File: 4072-14-4.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: Methanone, (2-hydroxy-4,5-dimethylphenyl)phenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: Methanone, (2-hydroxy-4,5-dimethylphenyl)phenyl-(4072-14-4)
• EPA Substance Registry System: Methanone, (2-hydroxy-4,5-dimethylphenyl)phenyl-(4072-14-4)

Safety Data

• Hazardous Substances Data: 4072-14-4(Hazardous Substances Data)

Upstream product

• 95-65-8 3,4-Dimethylphenol 
• 98-88-4 benzoyl chloride 
• 7446-70-0 aluminium trichloride 
• 5554-28-9 (3,5-Dimethylphenyl)benzoat 
• 2571-39-3 (3,4-dimethylphenyl)(phenyl)methanone 
• 143815-10-5 benzoic acid-(2-bromo-4,5-dimethyl-phenyl ester) 
• 4072-15-5 (4,5-dimethyl-2-methoxyphenyl)(phenyl)methanone 
• 3845-63-4 3,4-dimethylphenyl benzoate 
• 2929-45-5 (2-hydroxy-4,6-dimethylphenyl)(phenyl)methanone 
• 149696-45-7 1-benzoyl-2-difluoroboryloxy-4,5-dimethylbenzene 

Downstream Products

• 391688-77-0 ethyl 2-(6,7-dimethyl-2-oxo-4-phenyl-2H-chromen-3-yl)acetate 
• 149696-45-7 1-benzoyl-2-difluoroboryloxy-4,5-dimethylbenzene 

Relevant articles and documents

Discovery of a potent and orally available acyl-CoA: Cholesterol acyltransferase inhibitor as an anti-atherosclerotic agent: (4-Phenylcoumarin) acetanilide derivatives

Acyl-CoA: cholesterol acyltransferase (ACAT) is an intracellular enzyme that catalyzes cholesterol esterification. ACAT inhibitors are expected to be potent therapeutic agents for the treatment of atherosclerosis. A series of potent ACAT inhibitors based on an (4-phenylcoumarin)acetanilide scaffold was identified. Evaluation of the structure-activity relationships of a substituent on this scaffold, with an emphasis on improving the pharmacokinetic profile led to the discovery of 2-[7-chloro-4-(3-chlorophenyl)-6-methyl-2-oxo-2H-chromen-3- yl]-N-[4-chloro-2-(trifluoromethyl)phenyl]acetamide (23), which exhibited potent ACAT inhibitory activity (IC50=12 nM) and good pharmacokinetic profile in mice. Compound 23 also showed regressive effects on atherosclerotic plaques in apolipoprotein (apo)E knock out (KO) mice at a dose of 0.3 mg/kg per os ( p.o.).

CHELATES FROM THE REACTIONS OF CARBOXYLIC ACIDS WITH 3,4-XYLENOL IN THE PRESENCE OF BORON TRIFLUORIDE ETHER COMPLEX

Reactions of 3,4-xylenol with acetic, propionic, butyric, valeric, phenylacetic, and benzoic acids catalyzed by boron trifluoride ether complex give hitherto unknown BF2-containing chelates, which are converted into the corresponding ketones when heated with aqueous ethanol.The chelates and ketones were characterized by spectral data.