40732-48-7

Basic information

• Product Name: GUANOSINE 3':5'-CYCLIC MONOPHOSPHATE SODIUM SALT
• Synonyms: guanosine-3’,5’-cyclicmonophosphate(cgmp),sodiumsalt;CGMP SODIUM SALT;CGMP NA;CYCLIC GMP SODIUM SALT;GUANOSINE 3',5'-CYCLOPHOSPHATE MONOSODIUM SALT;GUANOSINE 3',5'-MONOPHOSPHATE MONOSODIUM SALT;GUANOSINE 3':5'-CYCLIC MONOPHOSPHATE SODIUM SALT;GUANOSINE-3',5'-CYCLIC MONOPHOSPHATE SODIUM SALT
• CAS NO: 40732-48-7
• Molecular Formula: C10H11N5NaO7P
• Molecular Weight: 367.19
• EINECS: 255-056-0
• Mol File: 40732-48-7.mol
• Article Data: 0

Chemical Properties

• Appearance: white/powder
• Storage Temp.: −20°C
• Solubility: H2O: 50 mg/mL
• BRN: 6467425
• CAS DataBase Reference: GUANOSINE 3':5'-CYCLIC MONOPHOSPHATE SODIUM SALT(CAS DataBase Reference)
• NIST Chemistry Reference: GUANOSINE 3':5'-CYCLIC MONOPHOSPHATE SODIUM SALT(40732-48-7)
• EPA Substance Registry System: GUANOSINE 3':5'-CYCLIC MONOPHOSPHATE SODIUM SALT(40732-48-7)

Safety Data

• WGK Germany: 3
• F: 10-21
• Hazardous Substances Data: 40732-48-7(Hazardous Substances Data)

Usage

Description

GUANOSINE 3':5'-CYCLIC MONOPHOSPHATE SODIUM SALT, also known as cGMP sodium salt, is a substituted guanosine with cyclic phosphodiesterase activity. It is a white powder and plays a crucial role in various biological processes, including signal transduction and regulation of cellular functions.

Uses

Used in Pharmaceutical Industry:
GUANOSINE 3':5'-CYCLIC MONOPHOSPHATE SODIUM SALT is used as a signaling molecule for the regulation of cellular processes. It is involved in the transmission of signals within cells, leading to various physiological responses.
Used in Research Applications:
In the field of research, GUANOSINE 3':5'-CYCLIC MONOPHOSPHATE SODIUM SALT is used as a biochemical tool to study the role of cyclic nucleotides in cellular signaling pathways. It helps researchers understand the mechanisms of various diseases and develop potential therapeutic strategies.
Used in Drug Development:
GUANOSINE 3':5'-CYCLIC MONOPHOSPHATE SODIUM SALT is used as a potential therapeutic agent in the development of drugs targeting cyclic nucleotide-related diseases. Its ability to modulate cellular signaling pathways makes it a promising candidate for the treatment of various conditions, such as cardiovascular diseases and certain types of cancer.
Used in Diagnostic Applications:
In the diagnostic industry, GUANOSINE 3':5'-CYCLIC MONOPHOSPHATE SODIUM SALT can be used as a biomarker to detect and monitor the progression of diseases related to cyclic nucleotide imbalances. Its measurement in biological samples can provide valuable information about the patient's health status and guide treatment decisions.

Biochem/physiol Actions

An important second messenger, cGMP is a major intracellular mediator of extracellular signals such as nitric oxide and natriuretic peptides. Cyclic GMP interacts with three types of intracellular receptor proteins: cGMP-dependent protein kinases, cGMP-regulated channels, and cGMP-regulated cyclic nucleotide phosphodiesterases. A primary action of elevated cGMP levels in vivo is the stimulation of cGMP-dependent protein kinase (PKG).