407578-45-4

Basic information

• Product Name: (3S,6S)-3-isopropyl-6-(cyclohexylmethyl)piperazine-2,5-dione
• Synonyms: (3S,6S)-3-isopropyl-6-(cyclohexylmethyl)piperazine-2,5-dione
• CAS NO: 407578-45-4
• Molecular Weight: 252.357
• Mol File: 407578-45-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (3S,6S)-3-isopropyl-6-(cyclohexylmethyl)piperazine-2,5-dione(CAS DataBase Reference)
• NIST Chemistry Reference: (3S,6S)-3-isopropyl-6-(cyclohexylmethyl)piperazine-2,5-dione(407578-45-4)
• EPA Substance Registry System: (3S,6S)-3-isopropyl-6-(cyclohexylmethyl)piperazine-2,5-dione(407578-45-4)

Safety Data

• Hazardous Substances Data: 407578-45-4(Hazardous Substances Data)

Upstream product

• 219916-54-8 (S)-N,N'-bis(p-methoxybenzyl)-3-methylene-6-isopropylpiperazine-2,5-dione 
• 205517-34-6 (3S)-N,N'-bis-(p-methoxybenzyl)-3-isopropyl-piperazine-2,5-dione 
• 219916-56-0 (3S,6S)-N,N'-bis(4-methoxybenzyl)-3-isopropyl-6-(cyclohexylmethyl)piperazine-2,5-dione 

Downstream Products

• 25528-71-6 (S)-2-amino-3-cyclohexylpropionic acid hydrochloride 
• 4070-48-8 L-Valine methyl ester 
• 40056-18-6 methyl L-cyclohexylalaninate 

Relevant articles and documents

Conjugate additions of organocuprates to a 3-methylene-6-isopropyldiketopiperazine acceptor for the asymmetric synthesis of homochiral α-amino acids

Addition of a range of organocuprates to (S)-N,N′-bis(p-methoxybenzyl)-3-methylene-6-isopropylpiperazine-2, 5-dione 8 affords cis-3-isopropyl-6-alkyldiketopiperazines in excellent yield and >95% de. Subsequent deprotection and hydrolysis of these cis-3-isopropyl-6-alkyldiketopiperazines affords homochiral (S)-α-amino acids in excellent yield.