40828-51-1

Basic information

• Product Name: 2-oxo-1,2-dihydro-pyrimidine-5-sulfonic acid
• Synonyms: 2-oxo-1,2-dihydro-pyrimidine-5-sulfonic acid;2-hydroxypyriMidine-5-sulfonic acid;2-hydroxy-5-pyrimidinesulfonic acid;2-Hydroxy-pyrimidine-5-sulphonicacid
• CAS NO: 40828-51-1
• Molecular Formula: C4H4N2O4S
• Molecular Weight: 176
• Mol File: 40828-51-1.mol
• Article Data: 6

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-oxo-1,2-dihydro-pyrimidine-5-sulfonic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2-oxo-1,2-dihydro-pyrimidine-5-sulfonic acid(40828-51-1)
• EPA Substance Registry System: 2-oxo-1,2-dihydro-pyrimidine-5-sulfonic acid(40828-51-1)

Safety Data

• Hazardous Substances Data: 40828-51-1(Hazardous Substances Data)

Usage

General Description

2-oxo-1,2-dihydro-pyrimidine-5-sulfonic acid, also known as uracil-2-sulfonic acid, is a chemical compound that belongs to the pyrimidine class of heterocyclic organic compounds. It is a sulfonic acid derivative of uracil, which is a common component of nucleic acids. 2-oxo-1,2-dihydro-pyrimidine-5-sulfonic acid is used as a building block in organic synthesis and can be found in some pharmaceutical drugs and biochemical research applications. It has potential uses in the development of new anti-cancer and anti-viral drugs due to its ability to inhibit the replication of certain DNA and RNA viruses. Its structure and properties make it a valuable tool for the study of biological processes and the development of new drugs and therapies.

Upstream product

• 109-12-6 2-aminopyrimidine 
• 31462-54-1 2-iodopyrimidine 
• 1722-12-9 2-chloropyrimidine 
• 4595-60-2 2-bromopyrimidine 
• 39687-77-9 2-amino-5-pyrimidinesulfonic acid 

Downstream Products

• 98026-88-1 2-chloro-pyrimidine-5-sulfonyl chloride 

Relevant articles and documents

Simple preparation method of 2-hydroxy-5-sulfonyl pyrimidine

The invention discloses a simple preparation method of 2-hydroxyl-5-sulfonyl pyrimidine. The preparation method comprises the following steps: taking 2-halogenated pyrimidine as a raw material; reacting with chlorosulfonic acid at a certain temperature; realizing the direct preparation of the 2-hydroxy-5-sulfonyl pyrimidine; after the reaction, performing standing overnight, filtering the product,washing with an organic solvent, and drying the product to obtain pure 2-hydroxy-5 sulfonyl pyrimidine. According to the present invention, the process has advantages of mild reaction condition, simple operation process, high product yield and the like, is suitable for industrial scale production, and provides the effective approach for the preparation of related compounds and derivatives thereof.

Acid secretion inhibitor

The present invention provides a compound having a superior acid secretion inhibitory effect and showing an antiulcer activity and the like. The present invention provides a compound represented by the formula (I) wherein R1 is a nitrogen-containing monocyclic heterocyclic group optionally condensed with a benzene ring or a heterocycle, the nitrogen-containing monocyclic heterocyclic group optionally condensed with a benzene ring or a heterocycle optionally has substituent(s), R2 is an optionally substituted C6-14 aryl group, an optionally substituted thienyl group or an optionally substituted pyridyl group, R3 and R4 are each a hydrogen atom, or one of R3 and R4 is a hydrogen atom and the other is an optionally substituted lower alkyl group, an acyl group, a halogen atom, a cyano group or a nitro group, and R5 is an alkyl group or a salt thereof.

PROTON PUMP INHIBITORS

Proton pump inhibitors which have excellent proton pumping activity and which can be converted in vivo into proton pump inhibitors to exhibit antiulcer effect and so on, containing compounds represented by the general formula (I) or salts thereof or prodrugs of the same: (I) wherein X and Y are each independently a free valency or a spacer whose main chain has 1 to 20 carbon atoms; R1 is an optionally substituted hydrocarbon group or an optionally substituted heterocyclic group; R2, R3 and R4 are each independently hydrogen, an optionally substituted hydrocarbon group, optionally substituted thienyl, optionally substituted benzo[b]thienyl, optionally substituted furyl, optionally substituted pyridyl, optionally substituted pyrazolyl, optionally substituted pyrimidinyl, acyl, halogeno, cyano, or nitro; and R5 and R6 are each independently hydrogen or an optionally substituted hydrocarbon group.