408320-75-2

Basic information

• Product Name: ethyl 4-bromo-3-oxo-2-phenylbutanoate
• Synonyms: ethyl 4-bromo-3-oxo-2-phenylbutanoate
• CAS NO: 408320-75-2
• Molecular Weight: 285.137
• Mol File: 408320-75-2.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: ethyl 4-bromo-3-oxo-2-phenylbutanoate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 4-bromo-3-oxo-2-phenylbutanoate(408320-75-2)
• EPA Substance Registry System: ethyl 4-bromo-3-oxo-2-phenylbutanoate(408320-75-2)

Safety Data

• Hazardous Substances Data: 408320-75-2(Hazardous Substances Data)

Upstream product

• 623-73-4 diazoacetic acid ethyl ester 
• 70-11-1 α-bromoacetophenone 
• 5413-05-8 ethyl 2-phenylacetoacetate 

Downstream Products

• 103-79-7 1-phenyl-acetone 
• 5413-05-8 ethyl 2-phenylacetoacetate 

Relevant articles and documents

Regiospecific Homologation of Unsymmetrical Ketones

A method has been developed for the regiospecific homologation of unhindered unsymmetrical ketones.The procedure consists of preparation of a pure α-halo ketone, reaction of this derivative with ethyl diazoacetate and boron trifluoride etherate, removal of the halogen by zinc reduction, and finally decarbethoxylation with water at 230 deg C or with CaCl2*2H2O in dimethyl sulfoxide at 150 deg C.The method depends on the electron-withdrawing power of the α-halogen to prevent the migration of the attached carbon.A-Homo steroid ketones are most conveniently prepared by this method.The reaction of α-acetoxy ketones with ethyl diazoacetate also leads mainly to migration of the unsubstituted α'-carbon atom.