40835-18-5

Basic information

• Product Name: methyl (2E)-3-methyl-4-oxobut-2-enoate
• Synonyms: 2-butenoic acid, 3-methyl-4-oxo-, methyl ester, (2E)-; Methyl (2E)-3-methyl-4-oxobut-2-enoate
• CAS NO: 40835-18-5
• Molecular Formula: C₆H₈O₃
• Molecular Weight: 128.1259
• Mol File: 40835-18-5.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 197.908°C at 760 mmHg
• Flash Point: 77.732°C
• Density: 1.052g/cm³
• Vapor Pressure: 0.37mmHg at 25°C
• Refractive Index: 1.434
• CAS DataBase Reference: methyl (2E)-3-methyl-4-oxobut-2-enoate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl (2E)-3-methyl-4-oxobut-2-enoate(40835-18-5)
• EPA Substance Registry System: methyl (2E)-3-methyl-4-oxobut-2-enoate(40835-18-5)

Safety Data

• Hazardous Substances Data: 40835-18-5(Hazardous Substances Data)

Usage

General Description

Methyl (2E)-3-methyl-4-oxobut-2-enoate, also known as methyl 3-methyl-4-oxo-2-butenoate, is a chemical compound with the molecular formula C6H8O3. It is a colorless liquid with a fruity odor and is commonly used as a flavoring agent in the food and beverage industry. It is also used in the synthesis of pharmaceuticals and other organic compounds. Methyl (2E)-3-methyl-4-oxobut-2-enoate is considered to be relatively stable and non-reactive under normal conditions, but proper handling and storage procedures should still be followed to ensure safety.

Upstream product

• 109941-42-6 3-Methyl-4--crotonsaeuremethylester 
• 13866-57-4 (E)-methyl 4-hydroxy-3-methylbut-2-enoate 
• 109745-70-2 methyl glyoxylate methyl hemi-acetal 
• 51043-49-3 (E)-1-(N-morpholino)propene 
• 24720-64-7 2-(triphenylphosphoranylidene)propionaldehyde 
• 624-49-7 dimethylfumarate 
• 405897-14-5 dimethyl tartrate 
• 99016-62-3 (E)-3-Methyl-4-trimethylsilanyloxy-but-2-enoic acid methyl ester 
• 82884-40-0 methyl 2-methyl-3-<(trimethylsilyl)oxy>-1-cyclopropanecarboxylate 
• 924-50-5 Methyl 3,3-dimethylacrylate 
• 19041-17-9 methyl 4-bromo-3-methylbut-2-enoate 

Downstream Products

• 57380-64-0 (2E,4E)-5-Cyclohex-1-enyl-3-methyl-penta-2,4-dienoic acid methyl ester 
• 14538-58-0 3-methyl-5t-(2,6,6-trimethyl-cyclohex-1-enyl)-penta-2t,4-dienoic acid methyl ester 
• 144175-90-6 methyl 4-hydroxy-3-methyl-4-phenyl-(E)but-2-enoate 
• 120674-47-7 methyl 2-hydroxyretinoate 
• 76686-32-3 methyl 3-hydroxyretinoate 
• 62311-52-8 (2E) 1-benzyloxy-2-methyl-2-buten-4-ol 
• 332888-38-7 (2S,3R)-(3-benzyloxymethyl-3-methyl-oxiranyl)-methanol 
• 310887-98-0 4-benzyloxy-3-methylbut-2-enoic acid methyl ester 
• 332888-39-8 dibenzyl (2R,3R)-4-benzyloxy-2,3-epoxy-3-methylbut-1-yl phosphate 
• 42933-13-1 2-C-methyl-D-erythritol 
• 155688-13-4 ((2S,3S)-3-Benzyloxymethyl-3-methyl-oxiranyl)-methanol 
• 6890-91-1 (3RS,all-E)-hydroxyretinal 
• 120674-79-5 3-((1E,3E,5E,7E)-9-Hydroxy-3,7-dimethyl-nona-1,3,5,7-tetraenyl)-2,2,4-trimethyl-cyclohex-3-enol 
• 90359-08-3 all trans, 9-cis 2-hydroxyretinal 

Relevant articles and documents

The first synthesis of a noreremophilane isolated from the roots of Ligularia przewalskii

The total synthesis of a natural product noreremophilane has been achieved in just three steps from readily available starting materials. A highly stereo- and regio-selective Diels-Alder reaction was the key step in our synthesis.

Simple and versatile synthesis of branched polyols: (+)-2-C-methylerythritol and (+)-2-C-methylthreitol

The paper reports a new approach for the enantioselective synthesis of 2-C-methyl tetrols. The procedure has been utilized for preparing methylthreitol and methylerythritol, a putative intermediate in the mevalonate-independent biosynthesis of terpenoids in bacteria, algae and higher plants. The methodology offers straightforward access to related compounds and isotopically labeled derivatives. (C) 2000 Elsevier Science Ltd.

A Direct Route for the Synthesis of (E)-3-Alkyl-4-oxo-2-butenoic Acid Esters

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