408505-25-9

Basic information

• Product Name: (2R,3S)-5-Methoxy-2-((1R,2S)-2-methoxy-2-methyl-1-tritylsulfanylamino-pentyl)-3-((Z)-propenyl)-pyrrolidine-1-carboxylic acid tert-butyl ester
• CAS NO: 408505-25-9
• Molecular Weight: 644.919
• Mol File: 408505-25-9.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: (2R,3S)-5-Methoxy-2-((1R,2S)-2-methoxy-2-methyl-1-tritylsulfanylamino-pentyl)-3-((Z)-propenyl)-pyrrolidine-1-carboxylic acid tert-butyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: (2R,3S)-5-Methoxy-2-((1R,2S)-2-methoxy-2-methyl-1-tritylsulfanylamino-pentyl)-3-((Z)-propenyl)-pyrrolidine-1-carboxylic acid tert-butyl ester(408505-25-9)
• EPA Substance Registry System: (2R,3S)-5-Methoxy-2-((1R,2S)-2-methoxy-2-methyl-1-tritylsulfanylamino-pentyl)-3-((Z)-propenyl)-pyrrolidine-1-carboxylic acid tert-butyl ester(408505-25-9)

Safety Data

• Hazardous Substances Data: 408505-25-9(Hazardous Substances Data)

Upstream product

• 67-56-1 methanol 
• 408505-24-8 (2R,3S)-5-Hydroxy-2-((1R,2S)-2-methoxy-2-methyl-1-tritylsulfanylamino-pentyl)-3-((Z)-propenyl)-pyrrolidine-1-carboxylic acid tert-butyl ester 
• 471257-47-3 (1E,2S)-2-methoxy-2-methylpentanal S-tritylthioxime 
• 335637-15-5 ((((2S)-2-methoxy-2-methylpentyl)oxy)methyl)benzene 
• 335637-14-4 (2S)-1-(benzyloxy)-2-methyl-2-pentanol 
• 335692-86-9 [(2R,3R)-3-ethyl-2-methyloxiran-2-yl]methyl benzoate 
• 133964-47-3 (2S)-2-methyl-1,2-pentanediol 
• 123669-93-2 3,4-anhydro-1,2-dideoxy-4-methyl-D-threo-pentitol 
• 1567-14-2 methyl (2E)-2-methyl-2-pentenoate 
• 16958-19-3 (2E)-2-methyl-2-penten-1-ol 
• 471257-46-2 (2S)-2-methoxy-2-methyl-pentanoic acid 
• 471257-45-1 (+/-)-methyl 2-methoxy-2-methyl pentanoate 
• 408505-23-7 tert-butyl (2R,3S)-2-{(1R,2S)-2-methoxy-2-methyl-1-[(triphenylmethylsulfenyl)amino]pentyl}-5-oxo-3-[(1Z)-prop-1-enyl]pyrrolidine-1-carboxylate 
• 471257-44-0 (2S)-2-methoxy-2-methyl-pent-1-ol 

Downstream Products

• 335679-69-1 A-315675 
• 408505-26-0 tert-butyl (2R,3S,5R)-5-cyano-2-{(1R,2S)-2-methoxy-2-methyl-1-[(tritylthio)amino]pentyl}-3-[(1Z)-prop-1-enyl]pyrrolidine-1-carboxylate 

Relevant articles and documents

A highly diastereoselective vinylogous Mannich condensation and 1,4-conjugate addition of (Z)-propenyl cuprate in the synthesis of an influenza neuraminidase inhibitor

A practical synthesis of neuraminidase influenza inhibitor, A-322278, has been developed. Asymmetry is introduced into the synthesis by an enzyme mediated ester hydrolysis. A highly diastereoselective vinylogous Mannich condensation reaction of N-Boc-2-te