40891-07-4Relevant articles and documents
Efficient synthesis of symmetrical bisamides catalyzed by reusable hydroxyapatite
Ramachandran, Gurusamy,Saraswathi, Ramachandran,Kumarraja, Mayilvasagam,Govindaraj, Palsamy,Subramanian, Thirumeni
, p. 216 - 222 (2018)
Efficient synthesis of symmetrical bisamides is achieved by hydroxyapatite catalyst. Hydroxyapatite catalyzes the reaction between aldehydes and amides to afford bisamides at reflux conditions in 87–95% yields in acetonitrile medium. The catalyst is readily recovered and reused at least three times without loss in its catalytic activity. This method is noteworthy that, symmetrical bisamides are synthesized by fast, simple, effective, and environmentally benign heterogeneous protocol.
N,N,N′,N′-tetramethylethylene-diaminium-N,N′-disulfonic acid trifluoroacetate and pyridinium-N-sulfonic acid hydrogen sulfate as highly effective dual-functional catalysts for the preparation of N,N′-alkylidene bisamides
Kordrostami, Zahra,Zare, Abdolkarim,Karami, Mostafa
, (2019/08/20)
In this research, Br?nsted-acidic ionic liquids N,N,N′,N′-tetramethylethylene-diaminium-N,N′-disulfonic acid trifluoroacetate ([TMEDSA][TFA]2) and pyridinium-N-sulfonic acid hydrogen sulfate ([Py-SO3H][HSO4]) have been introduced as dual-functional catalysts for the green, simple and effective preparation of N,N′-alkylidene bisamides by the reaction of primary amides (2 eq.) with arylaldehydes (1 eq.) under solvent-free conditions. The reaction results and conditions of the catalysts have been compared with the previously reported ones. [TMEDSA][TFA]2 and [Py-SO3H][HSO4] were superior to the previously reported catalysts in terms of two or more of these factors: Reaction times (10-45 min), yields (86-98%), temperature and the reaction conditions. Additionally, a plausible and attractive mechanism based on dual functionality of the catalysts has been proposed.
An efficient synthesis of bis(indolyl) methanes and N,N′-alkylidene bisamides by Silzic under solvent free conditions
Soliman, Hanan A.,Mubarak, Ahmed Y.,Elmorsy, Saad S.
, p. 353 - 356 (2016/03/16)
An operationally simple and green method for the synthesis of a wide range of bis(indolyl)methanes, and N,N′-alkylidene bisamides under mild conditions, with excellent yields using Silzic, has been developed. This improved method furnishes in good yields bis(indolyl)methanes derivatives starting from indole and aldehydes, or ketones, and N,N′-alkylidene bisamides derivatives starting from acetamide and aldehydes. The catalytic system was reused up to three times with the same efficiency.
