40896-58-0 Usage
Main properties
1. Chemical compound
2. Nucleoside derivative
3. Contains 6-chloro-2-bromo-9H-purine core
4. Attached to beta-D-ribofuranosyl group
5. Acetylated at 2, 3, and 5 positions
Specific content
1. Nucleobase: purine
2. Sugar: ribose
3. Substituents: chloro and bromo
4. Acetyl groups
5. Unique chemical and biological properties
6. Potential as antiviral or antitumor agent
7. Use in biochemical research and drug development
8. Role in modulating pharmacokinetic and pharmacodynamic properties
Check Digit Verification of cas no
The CAS Registry Mumber 40896-58-0 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 4,0,8,9 and 6 respectively; the second part has 2 digits, 5 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 40896-58:
(7*4)+(6*0)+(5*8)+(4*9)+(3*6)+(2*5)+(1*8)=140
140 % 10 = 0
So 40896-58-0 is a valid CAS Registry Number.
40896-58-0Relevant articles and documents
Nucleic acid related compounds. 118. Nonaqueous diazotization of aminopurine derivatives. Convenient access to 6-halo- and 2,6-dihalopurine nucleosides and 2′-deoxynucleosides with acyl or silyl halides
Francom, Paula,Robins, Morris J.
, p. 666 - 669 (2003)
Treatment of 9-(2,3,5-tri-O-acetyl-β-D-ribofuranosyl)-2-amino-6-chloropurine (1) with TMS-Cl and benzyltriethylammonium nitrite (BTEA-NO2) in dichloromethane gave the crystalline 2,6-dichloropurine nucleoside 2, and acetyl chloride/BTEA-NO2 was equally effective (～85%, without chromatography). TMS-Br/tert-butyl nitrite/dibromomethane gave crystalline 2-bromo-6-chloro analogue 3 (85%). (Chloro or bromo)-dediazoniation of 3′,5′-di-O-acetyl-2′-deoxyadenosine (4) gave the 6-[chloro (5, 63%) or bromo (6, 80%)]purine deoxynucleosides, and 2′,3′,5′-tri-O-acetyladenosine (8) was converted into the 6-chloropurine nucleoside 9 (71%).
