40924-27-4

Basic information

• Product Name: 2-Methoxymalonic acid diethyl ester
• Synonyms: 2-Methoxymalonic acid diethyl ester;diethyl 2-methoxymalonate
• CAS NO: 40924-27-4
• Molecular Formula: C₈H₁₄O₅
• Molecular Weight: 190.19
• Mol File: 40924-27-4.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 69 °C(Press: 0.2 Torr)
• Appearance: /
• Density: 1.091±0.06 g/cm3(Predicted)
• PKA: 13.09±0.46(Predicted)
• CAS DataBase Reference: 2-Methoxymalonic acid diethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Methoxymalonic acid diethyl ester(40924-27-4)
• EPA Substance Registry System: 2-Methoxymalonic acid diethyl ester(40924-27-4)

Safety Data

• Hazardous Substances Data: 40924-27-4(Hazardous Substances Data)

Upstream product

• 3938-96-3 ethyl 2-methoxyacetate 
• 105-58-8 Diethyl carbonate 
• 64-17-5 ethanol 
• 5018-30-4 dimethyl methoxymalonate 
• 67-56-1 methanol 
• 76429-94-2 diethyl diazirine-3,3-dicarboxylte 
• 5256-74-6 1,3-diethyl 2-diazopropanedioate 
• 104-15-4 toluene-4-sulfonic acid 
• 6290-49-9 methyl methoxyacetate 
• 95-92-1 oxalic acid diethyl ester 

Downstream Products

• 5018-31-5 methoxymalonic diamide 
• 35301-04-3 (2R,4R)-2,4-Dimethoxy-tridec-12-enoic acid methyl ester 
• 35301-02-1 (2S,4R)-2,4-Dimethoxy-tridec-12-enoic acid methyl ester 
• 35301-03-2 (2R,4S)-2,4-Dimethoxy-tridec-12-enoic acid methyl ester 
• 35301-05-4 (2S,4S)-2,4-Dimethoxy-tridec-12-enoic acid methyl ester 
• 5018-30-4 dimethyl methoxymalonate 
• 751-74-6 methoxy-[6β-(2-phenyl-acetylamino)-penicillanoyloxy]-malonic acid diethyl ester 
• 851985-99-4 2-methyl-4,6-dihydroxy-5-methoxy-pyrimidine 
• 71720-62-2 6-hydroxy-5-methoxy-1H-pyrimidine-2,4-dione,sodium salt 
• 1095274-42-2 ethyl [5-(3,5-dichlorophenyl)-1,3,4-oxadiazol-2-yl](methyloxy)acetate 
• 1095274-41-1 ethyl 3-{2-[(3,5-dichlorophenyl)carbonyl]hydrazino}-2-(methyloxy)-3-oxopropanoate 

Relevant articles and documents

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The reaction of dialkyl malonate esters with P2S5/S8 in boiling xylene in the presence of 2-mercaptobenzothiazole/ZnO as catalyst produces 5-alkylthio-3H-1,2-dithiole-3-thiones as major identifiable product. Moderate yields were obtained with malonate esters of primary alcohols. The reaction fails with malonate esters of secondary alcohols. Regarding the substituent in position two, dialkyl malonates with groups such as CH3, Ph, CH2Ph, OCH3 and Cl afford the corresponding 4-substituted derivatives whereas with Br and NO2 do not give the expected products. Some mechanistic evidences are described.

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