40925-28-8 Usage
Description
Ribavirin-5'-phosphate is a metabolite of Ribavirin, a nucleoside analog with antiviral properties. It plays a crucial role in inhibiting inosine monophosphate dehydrogenase (IMPDH), an enzyme involved in the synthesis of guanine nucleotides, which are essential for viral replication.
Uses
Used in Antiviral Applications:
Ribavirin-5'-phosphate is used as an antiviral agent for its ability to inhibit the replication of various viruses, including respiratory syncytial virus (RSV), influenza A and B, and hepatitis C virus (HCV). Its mechanism of action involves the disruption of the viral replication process by depleting the viral nucleotide pool and causing mutations in the viral genome.
Used in Respiratory Syncytial Virus (RSV) Treatment:
In the healthcare industry, ribavirin-5'-phosphate is used as a therapeutic agent for the treatment of severe RSV infections in infants and young children. It helps to reduce the severity and duration of the illness, as well as the risk of complications associated with RSV infection.
Used in Influenza Treatment:
Ribavirin-5'-phosphate is also used in the treatment of influenza A and B infections, particularly in cases where other antiviral medications are not effective or well-tolerated. Its antiviral activity helps to alleviate symptoms and shorten the duration of the illness.
Used in Hepatitis C Virus (HCV) Treatment:
In the field of hepatology, ribavirin-5'-phosphate is used in combination with other antiviral agents for the treatment of chronic hepatitis C infection. The combination therapy helps to improve the response rate and reduce the risk of viral resistance.
Overall, ribavirin-5'-phosphate is a versatile antiviral agent with applications in various medical fields, making it an essential component in the fight against viral infections.
Check Digit Verification of cas no
The CAS Registry Mumber 40925-28-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 4,0,9,2 and 5 respectively; the second part has 2 digits, 2 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 40925-28:
(7*4)+(6*0)+(5*9)+(4*2)+(3*5)+(2*2)+(1*8)=108
108 % 10 = 8
So 40925-28-8 is a valid CAS Registry Number.
InChI:InChI=1/C8H13N4O8P/c9-6(15)7-10-2-12(11-7)8-5(14)4(13)3(20-8)1-19-21(16,17)18/h2-5,8,13-14H,1H2,(H2,9,15)(H2,16,17,18)/t3-,4-,5-,8-/m1/s1
40925-28-8Relevant articles and documents
Synthesis and antiviral acticity of some phosphates of the broad-spectrum antiviral nucleoside, 1-beta-D-ribofuranosyl-1,2,4-triazole-3-carboxamide (ribavirin).
Allen,Boswell,Khwaja,Meyer Jr.,Sidwell,Witkowski,Christensen,Robins
, p. 742 - 746 (1978)
1-beta-D-Ribofuranosyl-1,2,4-triazole-3-carboxamide 5'-phosphate (2) was prepared and converted into the following derivatives: the 5'-phosphoramidate 3, the 5'-diphosphate 4, the 5'-triphosphate 5, and the cyclic 3',5'-phosphate 6. The cyclic 2',3'-phosp
Synthesis of Azole Nucleoside 5′-Monophosphate Mimics (P1Ms) and Their Inhibitory Properties of IMP Dehydrogenases
Wang, Guangyi,Sakthivel, Kandasamy,Rajappan, Vasanthakumar,Bruice, Thomas W.,Tucker, Kathleen,Fagan, Patrick,Brooks, Jennifer L.,Hurd, Tiffany,Leeds, Janet M.,Cook, P. Dan
, p. 317 - 337 (2007/10/03)
IMPDH inhibitors have potential antimicrobial, anticancer and immunomodulatory effects. Nucleoside inhibitors of IMPDH exert their inhibitory effects via nucleoside 5′-MPs. Conversion of nucleoside analogs to NMPs by cellular nucleoside kinases is not ass
