40926-72-5

Basic information

• Product Name: (3-methylphenoxy)acetyl chloride
• Synonyms: (3-methylphenoxy)acetyl chloride;acetyl chloride, (3-methylphenoxy)-;2-(3-methylphenoxy)acetyl chloride;2-(3-methylphenoxy)ethanoyl chloride
• CAS NO: 40926-72-5
• Molecular Formula: C₉H₉ClO₂
• Molecular Weight: 184.61956
• Mol File: 40926-72-5.mol
• Article Data: 24

Chemical Properties

• Appearance: /
• CAS DataBase Reference: (3-methylphenoxy)acetyl chloride(CAS DataBase Reference)
• NIST Chemistry Reference: (3-methylphenoxy)acetyl chloride(40926-72-5)
• EPA Substance Registry System: (3-methylphenoxy)acetyl chloride(40926-72-5)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 40926-72-5(Hazardous Substances Data)

Usage

Description

(3-methylphenoxy)acetyl chloride is a chemical compound with the molecular formula C9H9ClO2. It is a derivative of acetic acid and contains a 3-methylphenoxy group attached to an acetyl chloride group. (3-methylphenoxy)acetyl chloride is commonly used as a reagent in organic synthesis to introduce the (3-methylphenoxy)acetyl group into various organic molecules.

Uses

Used in Organic Synthesis:
(3-methylphenoxy)acetyl chloride is used as a reagent for introducing the (3-methylphenoxy)acetyl group into various organic molecules, which can enhance their properties or enable further chemical reactions.
Used in Pharmaceutical Production:
(3-methylphenoxy)acetyl chloride is used as a key intermediate in the synthesis of pharmaceuticals, contributing to the development of new drugs with specific therapeutic effects.
Used in Agrochemical Production:
(3-methylphenoxy)acetyl chloride is used in the production of agrochemicals, where it can be incorporated into molecules to improve their efficacy in agricultural applications.
Used in Specialty Chemicals Production:
(3-methylphenoxy)acetyl chloride is also utilized in the creation of specialty chemicals, where its unique properties can be leveraged for specific industrial applications.

Upstream product

• 1643-15-8 2-(m-tolyloxy)acetic acid 
• 144849-59-2 tert-Butyldimethylsilyl (m-tolyloxy)acetate 
• 66047-01-6 ethyl 3-methylphenoxyacetate 
• 108-39-4 3-methyl-phenol 
• 3019-89-4 sodium 3-methylphenoxide 
• 79-11-8 chloroacetic acid 
• 63051-20-7 m-tolyloxyacetic acid methyl ester 

Downstream Products

• 20895-41-4 6-methylbenzofuran-3(2H)-one 
• 2021-05-8 4-m-tolyloxyacetyl-morpholine 
• 57628-15-6 N-[1,3,4]thiadiazol-2-yl-2-m-tolyloxy-acetamide 
• 57628-27-0 N-(5-ethyl-[1,3,4]thiadiazol-2-yl)-2-m-tolyloxy-acetamide 
• 57628-33-8 N-(5-propyl-[1,3,4]thiadiazol-2-yl)-2-m-tolyloxy-acetamide 
• 64994-71-4 2-(4-methoxy-phenyl)-5-m-tolyloxyacetyl-5H-oxazolo[4,5-b]phenoxazine 
• 64994-87-2 2-(2-hydroxy-phenyl)-5-m-tolyloxyacetyl-5H-oxazolo[4,5-b]phenoxazine 
• 78961-70-3 1-Aziridin-1-yl-2-m-tolyloxy-ethanone 
• 143999-87-5 1-Piperazin-1-yl-2-m-tolyloxy-ethanone 
• 137537-10-1 1-Benzoimidazol-1-yl-2-m-tolyloxy-ethanone 
• 136776-27-7 1-Phenothiazin-10-yl-2-m-tolyloxy-ethanone 
• 144849-60-5 Ethyl 6-(3-Methylphenoxymethyl)nicotinoate 
• 134145-74-7 1-Carbazol-9-yl-2-m-tolyloxy-ethanone 
• 2021-12-7 m-Tolyloxyessigsaeure-(2-dimethylamino-ethylester) 

Relevant articles and documents

Design and Synthesis of Novel 4-Hydroxyl-3-(2-phenoxyacetyl)-pyran-2-one Derivatives for Use as Herbicides and Evaluation of Their Mode of Action

In order to develop a novel herbicide containing the β-triketone motif, a series of 4-hydroxyl-3-(2-phenoxyacetyl)-pyran-2-one derivatives were designed and synthesized. The bioassay results showed that compound II15 had good pre-emergent herbicidal activity even at a dosage of 187.5 g ha-1. Moreover, compound II15 showed a broader spectrum of weed control when compared with a commercial herbicide 2,4-dichlorophenoxyacetic acid (2,4-D), and displayed good crop safety to Triticum aestivum L. and Zea mays Linn. when applied at 375 g ha-1 under pre-emergence conditions, which indicated its great potential as a herbicide. More importantly, studying the molecular mode of action of compound II15 revealed that the novel triketone structure is a proherbicide of its corresponding phenoxyacetic acid auxin herbicide, which has a herbicidal mechanism similar to that of 2,4-D. The present work indicates that the 4-hydroxyl-3-(2-phenoxyacetyl)-pyran-2-one motif may be a potential lead structure for further development of novel auxin-type herbicides.

Synthesis and Biological Activity of 4-[(Substituted Phenoxyacetoxy)methyl]-2,6,7-trioxa-1-phosphabicyclo[2.2.2]octane-1-one

A series of novel 4-[(substituted phenoxyacetoxy)methyl]-2,6,7-trioxa-1-phosphabicyclo[2.2.2]octane-1-one 4a, 4b, 4c, 4d, 4e, 4f, 4g, 4h, 4i, 4j, 4k, 4l, 4m, 4n, 4o were synthesized. Their structures were confirmed by IR,1H NMR, mass spectroscopy, and elemental analyses. The results of preliminary bioassays show that some of the title compounds exhibit moderate to good herbicidal and fungicidal activities. For example, the title compounds 4b, 4c, 4f, 4h, 4i, and 4j possess 90–100% inhibition against the growth of roots of both rape and barnyard grass at 10 mg/L. Moreover, the title compounds 4f, 4g, and 4h possess 75–89% inhibition against Botrytis cinerea at the concentration of 50 mg/L.

Isoflavone amide derivatives, their preparation method and medical use

The invention belongs to the field of medicinal chemistry, and relates to derivatives of isoflavones amides, as well as a preparation method and medical application of derivatives, in particular to the derivatives of the isoflavones amides with the general formula of (I) shown as the specification, the preparation method and the medical application of the derivatives, particularly the application of the derivatives of the isoflavones amides serving as medicaments for preventing or treating hyperlipemia, adiposis or type-II diabetes.