4094-38-6

Basic information

• Product Name: 4-(p-Tolylsulfonyl)aniline
• Synonyms: 4-(p-Tolylsulfonyl)aniline;4-[(4-Methylphenyl)sulfonyl]aniline;4-[(4-Methylphenyl)sulfonyl]benzenamine
• CAS NO: 4094-38-6
• Molecular Formula: C₁₃H₁₃NO₂S
• Molecular Weight: 247.31
• Mol File: 4094-38-6.mol
• Article Data: 10

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 4-(p-Tolylsulfonyl)aniline(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(p-Tolylsulfonyl)aniline(4094-38-6)
• EPA Substance Registry System: 4-(p-Tolylsulfonyl)aniline(4094-38-6)

Safety Data

• Hazardous Substances Data: 4094-38-6(Hazardous Substances Data)

Upstream product

• 4094-37-5 4-nitrophenyl 4-toluenesulfonate 
• 4094-39-7 4-(acetamino)phenyl 4-methylphenyl sulfone 
• 5667-64-1 4-methyl-N-phenyl-N-tosylbenzenesulfonamide 
• 142-04-1 aniline hydrochloride 
• 104-15-4 toluene-4-sulfonic acid 
• 536-57-2 p-toluene sulfinic acid 
• 100-65-2 N-Phenylhydroxylamine 
• 103-84-4 Acetanilid 
• 98-59-9 p-toluenesulfonyl chloride 
• 68-34-8 phenyl toluenesulfonamide 
• 2903-34-6 4-methyl-N-(4-chlorophenyl)benzenesulfonamide 
• 51176-55-7 (+/-)-4-aminophenyl 4-methylphenyl sulfoxide 
• 418767-54-1 (+/-)-4-(acetamino)phenyl 4-methylphenyl sulfoxide 
• 62-53-3 aniline 

Downstream Products

• 859491-77-3 toluene-4-sulfonic acid-[4-(toluene-4-sulfonyl)-anilide] 
• 37924-24-6 4-(4-Methylphenylsulfonyl)-trifluormethansulfonanilid 
• 4094-40-0 4'-Acetamino-4-diacetoxymethyl-diphenylsulfon 
• 138384-65-3 6-{[4-(4-Amino-benzenesulfonyl)-benzyl]-methyl-amino}-1H-benzo[cd]indol-2-one 
• 138384-82-4 6-{[4-(4-Amino-benzenesulfonyl)-benzyl]-methyl-amino}-5-methyl-1H-benzo[cd]indol-2-one 
• 138384-85-7 [4-(4-Amino-benzenesulfonyl)-benzyl]-(2-imino-5-methyl-1,2-dihydro-benzo[cd]indol-6-yl)-methyl-amine 
• 856196-43-5 (4-chloro-3-nitro-phenyl)-p-tolyl sulfone 
• 860585-76-8 2-nitro-4-(toluene-4-sulfonyl)-aniline 

Relevant articles and documents

Cross-Coupling of Sodium Sulfinates with Aryl, Heteroaryl, and Vinyl Halides by Nickel/Photoredox Dual Catalysis

An efficient photoredox/nickel catalyzed sulfonylation reaction of aryl, heteroaryl, and vinyl halides has been achieved for the first time. This newly developed sulfonylation protocol provides a versatile method for the synthesis of diverse aromatic sulfones at room temperature and shows excellent functional group tolerance. The electrophilic coupling partners are not limited to aryl, heteroaryl, and vinyl bromides and iodides, but also includes less reactive aryl chlorides as suitable substrates for this transformation.

Triflic acid–catalyzed rearrangement of unalkylated benzene sulfonanilides

ABSTRACT: Previous work has demonstrated that alkylated benzene sulfonanilides undergo sulfuric acid (98%)–catalyzed rearrangement to alkylamino diaryl sulfones. Similar treatment of their unalkylated analogs typically leads only to hydrolysis. Surprisingly, when the unalkylated benzene sulfonanilides react with triflic acid, rearrangement to sulfones does occur.

Electron beam-induced fries rearrangement of sulfonamide and sulfonate crystals

The electron beam (EB) sensitivity of sulfonic acid derivatives in the crystalline state was much higher than that of the corresponding carboxylic acid derivatives, which was distinct from the results using other energy sources such as heat and UV; especially, sulfonamide derivatives could undergo the chemoselective Fries rearrangement to give ortho and para products in the ratio of ca. 7/3 without the meta isomer. Copyright