4096-22-4

Basic information

• Product Name: 1,4-Dimorpholinobenzene
• Synonyms: 1,4-Dimorpholinobenzene
• CAS NO: 4096-22-4
• Molecular Formula: C₁₄H₂₀N₂O₂
• Molecular Weight: 248.32
• Product Categories: pharmacetical
• Mol File: 4096-22-4.mol
• Article Data: 15

Chemical Properties

• Boiling Point: 444.8°Cat760mmHg
• Flash Point: 139.7°C
• Appearance: /
• Density: 1.149g/cm³
• CAS DataBase Reference: 1,4-Dimorpholinobenzene(CAS DataBase Reference)
• NIST Chemistry Reference: 1,4-Dimorpholinobenzene(4096-22-4)
• EPA Substance Registry System: 1,4-Dimorpholinobenzene(4096-22-4)

Safety Data

• Hazardous Substances Data: 4096-22-4(Hazardous Substances Data)

Usage

Chemical structure

A benzene ring with two morpholino groups attached at the 1 and 4 positions.

Usage

Commonly used as a reactant in the synthesis of other organic compounds, such as dyes, pharmaceuticals, and pesticides.

Hazardous potential

Has the potential to be hazardous to human health and the environment.

Specific hazards

Skin and eye irritation, and may cause respiratory irritation if inhaled.

Safety precautions

It is important to handle 1,4-Dimorpholinobenzene with caution and in accordance with safety regulations to minimize the risk of exposure and harm.

Upstream product

• 111-44-4 3-oxa-1,5-dichloropentane 
• 106-50-3 1,4-phenylenediamine 
• 102-92-1 cinnamoyl chloride 
• 38112-33-3 1,4-dimorpholinocyclohexa-1,3-diene 
• 10487-71-5 crotonyl chloride 
• 814-68-6 acryloyl chloride 
• 920-46-7 Methacryloyl chloride 
• 110-91-8 morpholine 
• 670-80-4 4-cyclohexen-1-ylmorpholine 
• 108-94-1 cyclohexanone 
• 106-37-6 1.4-dibromobenzene 
• 106-46-7 para-dichlorobenzene 
• 2581-43-3 cyclohexane-1,4-diyl bis(4-methylbenzenesulfonate) 
• 624-38-4 para-diiodobenzene 

Relevant articles and documents

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Nickel-Catalyzed Amination of Aryl Thioethers: A Combined Synthetic and Mechanistic Study

Herein, we report a nickel-1,2-bis(dicyclohexylphosphino)ethane (dcype) complex for the catalytic Buchwald-Hartwig amination of aryl thioethers. The protocol shows broad applicability with a variety of different functional groups tolerated under the catalytic conditions. Extensive organometallic and kinetic studies support a nickel(0)-nickel(II) pathway for this transformation and revealed the oxidative addition complex as the resting state of the catalytic cycle. All the isolated intermediates have proven to be catalytically and kinetically competent catalysts for this transformation. The fleeting transmetalation intermediate has been successfully synthesized through an alternative synthetic organometallic pathway at lower temperature, allowing for in situ NMR study of the C-N bond reductive elimination step. This study addresses key factors governing the mechanism of the nickel-catalyzed Buchwald-Hartwig amination process, thus improving the understanding of this important class of reactions.

Synthesis and structural characterization of palladium(II) thiosemicarbazone complex: Application to the Buchwald-Hartwig amination reaction

A simple route to synthesize mononuclear palladium(II) thiosemicarbazone complex has been described. Elemental analysis, spectral methods and single crystal X-ray diffraction analysis were used to confirm the composition of the complex. The new complex acts as an active homogeneous catalyst for the Buchwald-Hartwig amination reaction of a wide range of aryl and heteroaryl halides (bromides and chlorides), including activating, neutral and deactivating substrates, with various secondary amines under optimized conditions.